Protein Info for KDGMDA_24635 in Klebsiella pneumoniae MKP103

Annotation: sodium-potassium/proton antiporter ChaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 366 transmembrane" amino acids 15 to 32 (18 residues), see Phobius details amino acids 38 to 59 (22 residues), see Phobius details amino acids 72 to 94 (23 residues), see Phobius details amino acids 106 to 126 (21 residues), see Phobius details amino acids 142 to 161 (20 residues), see Phobius details amino acids 169 to 188 (20 residues), see Phobius details amino acids 222 to 242 (21 residues), see Phobius details amino acids 252 to 270 (19 residues), see Phobius details amino acids 289 to 312 (24 residues), see Phobius details amino acids 319 to 340 (22 residues), see Phobius details amino acids 347 to 365 (19 residues), see Phobius details TIGR00846: calcium/proton exchanger" amino acids 2 to 365 (364 residues), 404 bits, see alignment E=2.6e-125 PF01699: Na_Ca_ex" amino acids 40 to 190 (151 residues), 61.3 bits, see alignment E=5.5e-21 amino acids 223 to 365 (143 residues), 29.9 bits, see alignment E=2.5e-11

Best Hits

Swiss-Prot: 93% identical to CHAA_ECOLI: Sodium-potassium/proton antiporter ChaA (chaA) from Escherichia coli (strain K12)

KEGG orthology group: K07300, Ca2+:H+ antiporter (inferred from 100% identity to kva:Kvar_1953)

MetaCyc: 93% identical to Na+/K+:H+ antiporter ChaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-101; TRANS-RXN-42

Predicted SEED Role

"Calcium/proton antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (366 amino acids)

>KDGMDA_24635 sodium-potassium/proton antiporter ChaA (Klebsiella pneumoniae MKP103)
MTHAHEAVKTRHKESSLVFPVLALAVLFFWGSSQSLPVVIAINILALVGILSSAFSVVRH
ADVLAHRLGEPYGSLILSLSVVILEVSLISALMATGDAAPTLMRDTLYSIIMIVTGGLVG
FSLLLGGRKFATQYMNLFGIKQYLIALFPLAIIVLVFPMALPGANFSTGQSLLVAVISAA
MYGVFLLIQTKTHQSLFVYEHEDDSDDDDPHHGKPSAHSSGWHTAWLLVHLVAVIAVTKM
NANPLETLLTSMNAPVAFTGFLVALLILSPEGLGALKAVLNNQVQRAMNLFFGSVLATIS
LTVPVVTLIAFLTGNELRFGLGAPEMVVMVASLVLCHISFSTGRTNVLNGAAHMALFAAY
LMTIFA