Protein Info for KDGMDA_07345 in Klebsiella pneumoniae MKP103

Annotation: UDP-4-amino-4-deoxy-L-arabinose aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 379 PF01041: DegT_DnrJ_EryC1" amino acids 12 to 374 (363 residues), 447.8 bits, see alignment E=6.6e-138 PF01053: Cys_Met_Meta_PP" amino acids 32 to 167 (136 residues), 31.4 bits, see alignment E=1.6e-11 PF01212: Beta_elim_lyase" amino acids 33 to 273 (241 residues), 29 bits, see alignment E=1.4e-10 PF00155: Aminotran_1_2" amino acids 35 to 161 (127 residues), 33.1 bits, see alignment E=7.4e-12

Best Hits

Swiss-Prot: 100% identical to ARNB_KLEP7: UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (arnB) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K07806, UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [EC: 2.6.1.87] (inferred from 100% identity to kpu:KP1_5185)

MetaCyc: 79% identical to UDP-4-amino-4-deoxy-L-arabinose aminotransferase (Escherichia coli K-12 substr. MG1655)
RXN0-1863 [EC: 2.6.1.87, 2.6.1.92]

Predicted SEED Role

"UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (EC 2.6.1.-)" in subsystem Lipid A-Ara4N pathway ( Polymyxin resistance ) (EC 2.6.1.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.-

Use Curated BLAST to search for 2.6.1.- or 2.6.1.87 or 2.6.1.92

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (379 amino acids)

>KDGMDA_07345 UDP-4-amino-4-deoxy-L-arabinose aminotransferase (Klebsiella pneumoniae MKP103)
MSDFLPFSRPSMGDAELAALREVLASGWITTGPKNQALEAAFCQLTGNRHAIAVSSATGG
MHVTLMALGIGPGDEVITPSQTWVSTLNMICLLGATPVMIDVDNDNLMITPAAVEAAITS
RTKAIIPVHYAGAPADIDAIRAVGERHGISVIEDAAHAAGTHYKGRHVGWQGTAIFSFHA
IKNMTCAEGGLIVTDDDELASRIRSLKFHGLGVDAYDRQTHGRAPQAEVITPGFKYNLAD
INAALALVQLEKLSHANQRRTEIAQRYLRELADTPFKPLSVPTWDHQHAWHLFIIRVDEA
ACGISRDALMEKLKAMGIGTGLHFRAAHTQKYYRERFPEVSLPNTEWNSARICSLPLFPD
MTDDDVTRVISALRQLSGR