Protein Info for JDDGAC_30235 in Escherichia coli ECRC98

Name: espP
Annotation: serine protease autotransporter EspP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 signal peptide" amino acids 38 to 38 (1 residues), see Phobius details amino acids 56 to 56 (1 residues), see Phobius details transmembrane" amino acids 39 to 55 (17 residues), see Phobius details PF02395: Peptidase_S6" amino acids 66 to 509 (444 residues), 147 bits, see alignment E=1e-46 TIGR01414: outer membrane autotransporter barrel domain" amino acids 890 to 1300 (411 residues), 248.7 bits, see alignment E=6e-78 PF03797: Autotransporter" amino acids 1041 to 1278 (238 residues), 133.8 bits, see alignment E=1.5e-42

Best Hits

Swiss-Prot: 100% identical to ESPP_ECO57: Serine protease EspP (espP) from Escherichia coli O157:H7

KEGG orthology group: K12684, serine protease autotransporter [EC: 3.4.21.-] (inferred from 100% identity to ece:L7020)

Predicted SEED Role

"Per-activated serine protease autotransporter enterotoxin EspC"

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1300 amino acids)

>JDDGAC_30235 serine protease autotransporter EspP (Escherichia coli ECRC98)
MNKIYSLKYSHITGGLIAVSELSGRVSSRATGKKKHKRILALCFLGLLQSSYSFASQMDI
SNFYIRDYMDFAQNKGIFQAGATNIEIVKKDGSTLKLPEVPFPDFSPVANKGSTTSIGGA
YSITATHNTKNHHSVATQNWGNSTYKQTDWNTSHPDFAVSRLDKFVVETRGATEGADISL
SKQQALERYGVNYKGEKKLIAFRAGSGVVSVKKNGRITPFNEVSYKPEMLNGSFVHIDDW
SGWLILTNNQFDEFNNIASQGDSGSALFVYDNQKKKWVVAGTVWGIYNYANGKNHAAYSK
WNQTTIDNLKNKYSYNVDMSGAQVATIENGKLTGTGSDTTDIKNKDLIFTGGGDILLKSS
FDNGAGGLVFNDKKTYRVNGDDFTFKGAGVDTRNGSTVEWNIRYDNKDNLHKIGDGTLDV
RKTQNTNLKTGEGLVILGAEKTFNNIYITSGDGTVRLNAENALSGGEYNGIFFAKNGGTL
DLNGYNQSFNKIAATDSGAIITNTSTKKSILSLNNTADYIYHGNINGNLDVLQHHETKKE
NRRLILDGGVDTTNDISLRNTQLSMQGHATEHAIYRDGAFSCSLPAPMRFLCGSDYVAGM
QNTEADAVKQNGNAYKTNNAVSDLSQPDWETGTFRFGTLHLENSDFSVGRNANVIGDIQA
SKSNITIGDTTAYIDLHAGKNITGDGFGFRQNIVRGSSQGETLFTGGITAEDSTIVIKDK
AKALFSNYVYLLNTKATIENGADVTTQSGMFSTSDISISGNLSMTGNPDKDNKFEPSIYL
NDASYLLTDDSARLVAKNKASVVGDIHSTKSASIMFGHDESDLSQLSDRTSKGLALGLLG
GFDVSYRGSVNAPSASATMNNTWWQLTGDSALKTLKSTNSMVYFTDSANNKKFHTLTVDE
LATSNSAYAMRTNLSESDKLEVKKHLSGENNILLVDFLQKPTPEKQLNIELVSAPKDTNE
NVFKASKQTIGFSDVTPVITTRETDDKITWSLTGYNTVANKEATRNAAALFSVDYKAFLN
EVNNLNKRMGDLRDINGEAGAWARIMSGTGSASGGFSDNYTHVQVGVDKKHELDGLDLFT
GFTVTHTDSSASADVFSGKTKSVGAGLYASAMFDSGAYIDLIGKYVHHDNEYTATFAGLG
TRDYSTHSWYAGAEAGYRYHVTEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKDKDYN
PLIGRTGVDVGKSFSGKDWKVTARAGLGYQFDLLANGETVLRDASGEKRIKGEKDSRMLM
SVGLNAEIRDNVRFGLEFEKSAFGKYNVDNAVNANFRYSF