Protein Info for JDDGAC_26075 in Escherichia coli ECRC98
Name: pbp4b
Annotation: penicillin binding protein PBP4B
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to YFEW_ECO57: Putative D-alanyl-D-alanine carboxypeptidase (yfeW) from Escherichia coli O157:H7
KEGG orthology group: None (inferred from 100% identity to ece:Z3695)MetaCyc: 98% identical to penicillin binding protein 4B (Escherichia coli K-12 substr. MG1655)
Serine-type D-Ala-D-Ala carboxypeptidase. [EC: 3.4.16.4]
Predicted SEED Role
No annotation
MetaCyc Pathways
- peptidoglycan biosynthesis II (staphylococci) (12/17 steps found)
- peptidoglycan biosynthesis IV (Enterococcus faecium) (12/17 steps found)
- peptidoglycan maturation (meso-diaminopimelate containing) (6/12 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 3.4.16.4
Use Curated BLAST to search for 3.4.16.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (434 amino acids)
>JDDGAC_26075 penicillin binding protein PBP4B (Escherichia coli ECRC98) MKRTMLYLSLLAVSCSVSAAKYPVLTESSPEKAGFNVERLNQMDRWISQQVDAGYPGVNL LIIKDNQIVYRKAWGAAKKYDGSVLMAQPVKATTGTLYDLASNTKMYATNFALQKLMSEG KLHPDDLIAKYISGFADSPNDTIKGKNTLRISDLLHHSGGFPADPQYPNKAVAGALYSQD KGQTLEMIKRTPLEYQPGSKHIYSDVDYMLLGFIVESVTGQPLDRYVEESIYRPLGLTHT VFNPLLKGFKPQQIAATELNGNTRDGVIHFPNIRTSTHWGQVHDEKAFYSMGGVSGHAGL FSNTGDIAVLMQTMLNGGGYGDVQLFSAETVKMFTTSSKEDATFGLGWRVNGNATMTPTF GTLASPQTYGHTGWTGTVTVIDPVNHMAIVMLSNKPHSPVADPQKNPNMFESGQLPIATY GWVVDQVYAALKQK