Protein Info for JDDGAC_17680 in Escherichia coli ECRC98

Name: melB
Annotation: MFS/sugar transport protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 461 transmembrane" amino acids 20 to 41 (22 residues), see Phobius details amino acids 53 to 72 (20 residues), see Phobius details amino acids 92 to 110 (19 residues), see Phobius details amino acids 121 to 143 (23 residues), see Phobius details amino acids 163 to 183 (21 residues), see Phobius details amino acids 189 to 210 (22 residues), see Phobius details amino acids 244 to 266 (23 residues), see Phobius details amino acids 278 to 297 (20 residues), see Phobius details amino acids 309 to 327 (19 residues), see Phobius details amino acids 333 to 356 (24 residues), see Phobius details amino acids 388 to 404 (17 residues), see Phobius details amino acids 420 to 442 (23 residues), see Phobius details TIGR00792: sugar (Glycoside-Pentoside-Hexuronide) transporter" amino acids 19 to 457 (439 residues), 535.9 bits, see alignment E=3.4e-165 PF13347: MFS_2" amino acids 21 to 444 (424 residues), 265.7 bits, see alignment E=5.9e-83 PF07690: MFS_1" amino acids 101 to 389 (289 residues), 38.1 bits, see alignment E=9.1e-14

Best Hits

Swiss-Prot: 99% identical to YIHP_ECOLI: Putative 2,3-dihydroxypropane-1-sulfonate exporter (yihP) from Escherichia coli (strain K12)

KEGG orthology group: K03292, glycoside/pentoside/hexuronide:cation symporter, GPH family (inferred from 99% identity to eco:b3877)

MetaCyc: 65% identical to putative sulfoquinovose transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-580

Predicted SEED Role

"Glucuronide transport protein YihP, homologous to YihO"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (461 amino acids)

>JDDGAC_17680 MFS/sugar transport protein (Escherichia coli ECRC98)
MSHITTEDPATLRLPFKEKLSYGIGDLASNILLDIGTLYLLKFYTDVLGLPGTYGGIIFL
ISKFFTAFTDMGTGIMLDSRRKIGPKGKFRPFILYASFPVTLLAIANFIGTPFDVTGKTV
MATILFMLYGLFFSMMNCSYGAMVPAITKNPNERASLAAWRQGGATLGLLLCTVGFVPVM
NLIEGNQQLGYIFAATLFSLFGLLFMWICYSGVKERYVETQPANPAQKPGLLQSFRAIAG
NRPLFILCIANLCTLGAFNVKLAIQVYYTQYVLNDPILLSYMGFFSMGCIFIGVFLMPGA
VRRFGKKKVYIGGLLIWVLGDLLNYFFSGGSVSFVAFSCLAFFGSAFVNSLNWALVSDTV
EYGEWRTGVRSEGTVYTGFTFFRKVSQALAGFFPGWMLTQIGYVPNVAQADHTIEGLRQL
IFIYPSALAVVTIVAMGCFYSLNEKMYVRIVEEIEARKRTA