Protein Info for JDDGAC_01035 in Escherichia coli ECRC98

Name: proQ
Annotation: RNA chaperone ProQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 232 PF04352: ProQ" amino acids 8 to 115 (108 residues), 139.4 bits, see alignment E=4.3e-45 PF17516: ProQ_C" amino acids 182 to 232 (51 residues), 83.2 bits, see alignment E=6.8e-28

Best Hits

Swiss-Prot: 100% identical to PROQ_SHIDS: RNA chaperone ProQ (proQ) from Shigella dysenteriae serotype 1 (strain Sd197)

KEGG orthology group: K03607, ProP effector (inferred from 99% identity to eco:b1831)

Predicted SEED Role

"ProQ: influences osmotic activation of compatible solute ProP" in subsystem Proline, 4-hydroxyproline uptake and utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (232 amino acids)

>JDDGAC_01035 RNA chaperone ProQ (Escherichia coli ECRC98)
MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVDRVAGEMNLSKTQLRSA
LRLYTSSWRYLYGVKPGATRVDLDGNPCGELDEQHVEHARKQLEEAKARVQAQRAEQQAK
KREAAAAAGEKEDAPRRERKPRPTTPRRKEGAERKPRAQKPVEKAPKTAKAPREEQHTPV
SDISALTVGQALKVKAGQNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF