Protein Info for IAI46_25255 in Serratia liquefaciens MT49

Annotation: membrane protein insertase YidC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 545 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 346 to 369 (24 residues), see Phobius details amino acids 415 to 437 (23 residues), see Phobius details amino acids 460 to 478 (19 residues), see Phobius details amino acids 491 to 516 (26 residues), see Phobius details TIGR03593: membrane protein insertase, YidC/Oxa1 family, N-terminal domain" amino acids 3 to 349 (347 residues), 392.2 bits, see alignment E=3.2e-121 PF14849: YidC_periplas" amino acids 61 to 340 (280 residues), 299.5 bits, see alignment E=3.7e-93 TIGR03592: membrane protein insertase, YidC/Oxa1 family" amino acids 350 to 530 (181 residues), 232.6 bits, see alignment E=4.1e-73 PF02096: 60KD_IMP" amino acids 351 to 530 (180 residues), 213.2 bits, see alignment E=2.2e-67

Best Hits

Swiss-Prot: 99% identical to YIDC_SERP5: Membrane protein insertase YidC (yidC) from Serratia proteamaculans (strain 568)

KEGG orthology group: K03217, preprotein translocase subunit YidC (inferred from 99% identity to spe:Spro_0028)

MetaCyc: 78% identical to membrane protein insertase YidC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-403

Predicted SEED Role

"Inner membrane protein translocase component YidC, long form"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (545 amino acids)

>IAI46_25255 membrane protein insertase YidC (Serratia liquefaciens MT49)
MDSQRNLLLIALLFVSFMIWQAWQTDNAPQPVAQTTQQTSNTATGDAASSAVPASGQGKL
ITVNTDVLSLTINTRGGDIEQAKLLAYPDTLGSSTPFQLLETTPSFVYQAQSGLTGRNGP
DNPANGERPLFQAAQDSYTLPEGQEELRIPLTFTGKDGAIYTKTFVLKRNHYAVAVDYNV
DNKGTTPLELTLFGQLKQTTELPKHRDTGSNNFALHTFRGAAYSSSEDKYQKYAFDKDEN
LSVTTQGGWVAMLQQYFATAWVPATQGSNTFYTAKPGDNLSTIGFKSTPVVVQPGAQQQL
NATLWVGPELQDQMAQLAPHLDLTVDYGWLWFISQPLFKLLKFIHGFIGNWGFSIIIITF
IVRGIMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDKQRMSQEMMALYKSEKVNPLGGC
LPLVIQMPIFLALYYMLMGSVELRHAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSP
TTVTDPMQQKIMTFMPVIFTVFFLWFPSGLVLYYIVSNLVTILQQQLIYRGLEKRGLHSR
DKKKT