Protein Info for IAI46_25240 in Serratia liquefaciens MT49

Annotation: SidA/IucD/PvdA family monooxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 PF13434: Lys_Orn_oxgnase" amino acids 4 to 334 (331 residues), 362.5 bits, see alignment E=4.6e-112 PF13738: Pyr_redox_3" amino acids 61 to 202 (142 residues), 35.7 bits, see alignment E=1.2e-12

Best Hits

Swiss-Prot: 52% identical to IUCD_ECOLX: L-lysine N6-monooxygenase (iucD) from Escherichia coli

KEGG orthology group: K03897, lysine N6-hydroxylase [EC: 1.14.13.59] (inferred from 92% identity to spe:Spro_0025)

MetaCyc: 52% identical to L-lysine 6-monooxygenase subunit (Escherichia coli K-12)
L-lysine 6-monooxygenase (NADPH). [EC: 1.14.13.59]

Predicted SEED Role

"L-lysine 6-monooxygenase [NADPH] (EC 1.14.13.59), aerobactin biosynthesis protein IucD @ Siderophore biosynthesis protein, monooxygenase" (EC 1.14.13.59)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.14.13.59

Use Curated BLAST to search for 1.14.13.59

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (437 amino acids)

>IAI46_25240 SidA/IucD/PvdA family monooxygenase (Serratia liquefaciens MT49)
MNEPLDLLGVGLGPFNLSLAALAYESGALNYAFLDRNASFRWHPGMLLPSAYMQTYVLQD
LVTAVTPRSQFSFINYLVEQKKIYRFLITEQQIISREEFSDYLSWACNRLEGLQFSQSVE
SIDFDDEKQLFKVRTRDQTLWAKNICLGTGHDPWLPEEFYPALGENCLHAAEIGLRNPDL
TGKRVAVIGGGQSGADIFLNALRGHWGEPAQLDWISRRPNFQPLDESAFTNEYFTPEYVD
YFYTLPQDIRERELKTQKLPADGISNHTLRTLYRELYMRFDVMHQPRNVRLLPHRTLLAI
EPTGKGFQLRTRHGLENRQEGFNADVVILATGYRPSLPAYLKPLLPRIPFDDQQHLPLLP
DFNLEWQGPEQNRIYAVNAGIHSHGSAEGGLSLMAWRSARILNHLLGKPHFDLAPNASLI
QWWSGAAPDDDITQTNK