Protein Info for IAI46_25220 in Serratia liquefaciens MT49

Annotation: NCS2 family permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 transmembrane" amino acids 32 to 50 (19 residues), see Phobius details amino acids 62 to 82 (21 residues), see Phobius details amino acids 89 to 110 (22 residues), see Phobius details amino acids 116 to 134 (19 residues), see Phobius details amino acids 144 to 164 (21 residues), see Phobius details amino acids 175 to 198 (24 residues), see Phobius details amino acids 205 to 222 (18 residues), see Phobius details amino acids 245 to 266 (22 residues), see Phobius details amino acids 295 to 317 (23 residues), see Phobius details amino acids 329 to 347 (19 residues), see Phobius details amino acids 355 to 374 (20 residues), see Phobius details amino acids 387 to 412 (26 residues), see Phobius details amino acids 424 to 442 (19 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 31 to 404 (374 residues), 147.2 bits, see alignment E=3e-47

Best Hits

Swiss-Prot: 86% identical to ADEP_ECOLI: Adenine permease AdeP (adeP) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 99% identity to srr:SerAS9_5017)

MetaCyc: 86% identical to adenine:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-447

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (445 amino acids)

>IAI46_25220 NCS2 family permease (Serratia liquefaciens MT49)
MSKPVSGLDVEQGLLGRVFKLKQHGTTARTETIAGITTFLTMVYIVFVNPQILGAAGMDT
QAVFVTTCLIAAFGSIFMGLLANLPVALAPAMGLNAFFAFVVVGAMGISWQIGMGAIFWG
AVGLLLLTIFRVRYWMIANIPMSLRVGITSGIGLFIGMMGLKNAGIVVANPDTLVTIGSL
TSHNVLLGALGFFIIAVLSSRNFHAAVLISIVVTTLIGWALGDVKYGGVFSMPPNITSVV
GQVDLAGALNIGLAGVIFSFMLVNLFDSSGTLIGVTDKAGLTDDKGKFPRMKQALYVDSI
SSVAGSFVGTSSVTAYIESSAGVSVGGRTGLTAVVTGILFLLVIFLSPLAGMVPAYAAAG
ALIYVGVLMTSSLARVKWDDLTEAVPAFVTAVMMPFSFSITEGIALGFISYCVMKLGTGR
WREISPCVVVVALLFVLKIVFVDGH