Protein Info for IAI46_25170 in Serratia liquefaciens MT49

Annotation: glutamine--fructose-6-phosphate transaminase (isomerizing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 609 (608 residues), 874.9 bits, E=1.6e-267
• PF13522: GATase_6
  • amino acids 65 to 183 (119 residues), 67.7 bits, E=1.6e-22
• PF13537: GATase_7
  • amino acids 82 to 196 (115 residues), 53.6 bits, E=3.3e-18
• PF01380: SIS
  • amino acids 290 to 418 (129 residues), 116.2 bits, E=1.4e-37
  • amino acids 462 to 591 (130 residues), 97.6 bits, E=7.9e-32

Best Hits

Swiss-Prot: 90% identical to GLMS_YERPS: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Yersinia pseudotuberculosis serotype I (strain IP32953)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 99% identity to spe:Spro_0011)

MetaCyc: 85% identical to L-glutamine--D-fructose-6-phosphate aminotransferase (Escherichia coli K-12 substr. MG1655)
Glutamine--fructose-6-phosphate transaminase (isomerizing). [EC: 2.6.1.16]

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• O-antigen building blocks biosynthesis (E. coli) (9/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Protein Sequence (609 amino acids)

>IAI46_25170 glutamine--fructose-6-phosphate transaminase (isomerizing) (Serratia liquefaciens MT49)
MCGIVGAVAQRDIAEILLEGLRRLEYRGYDSAGLAVVDAEGNVNRLRRVGKVNKLAEAAE
QHPLHGGTGIAHTRWATHGEPTEANAHPHVSDYITVVHNGIIENHEPLRELLIERGYHFS
SETDTEVIAHLVHWEQRQGGSLLEVVQRVIPQLRGAYGTVVMDSRDPSVLVAARSGSPLV
IGRGVGENFLASDQLALLPVTRRFIFLEEGDVVEMTRRTVNIFDKQGNAVERPEIESQVQ
YDAGDKGAYRHYMQKEIYEQPLALKNTLEGRFSHGQINLSELGPRADELLAKVQHVQIIA
CGTSYHSGMVARYWFESLAGVPCDVEIASEFRYRKSAVRPGSLIITLSQSGETADTLAAL
RLSKELGYLGSLAVCNVAGSSLVRESDLALMTKAGTEIGVASTKAFTTQLAVLLMLVARL
GRLKGMAESVEHEIVHGLQALPARIEQMLSLDKSIEALAEGFSDKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRAR
GGQLYVFADQDAGFVSSEGMTIIPLPHVEEIVAPIFYTVPLQLLSYHVALIKGTDVDQPR
NLAKSVTVE