Protein Info for IAI46_25080 in Serratia liquefaciens MT49

Annotation: low affinity potassium transporter Kup

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 622 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 48 to 69 (22 residues), see Phobius details amino acids 99 to 121 (23 residues), see Phobius details amino acids 136 to 156 (21 residues), see Phobius details amino acids 168 to 189 (22 residues), see Phobius details amino acids 213 to 233 (21 residues), see Phobius details amino acids 245 to 265 (21 residues), see Phobius details amino acids 285 to 312 (28 residues), see Phobius details amino acids 337 to 357 (21 residues), see Phobius details amino acids 363 to 386 (24 residues), see Phobius details amino acids 395 to 414 (20 residues), see Phobius details amino acids 422 to 440 (19 residues), see Phobius details PF02705: K_trans" amino acids 14 to 544 (531 residues), 734.5 bits, see alignment E=3.4e-225 TIGR00794: potassium uptake protein" amino acids 97 to 550 (454 residues), 621.9 bits, see alignment E=7.9e-191

Best Hits

Swiss-Prot: 87% identical to KUP_SALPB: Low affinity potassium transport system protein kup (kup) from Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

KEGG orthology group: K03549, KUP system potassium uptake protein (inferred from 87% identity to ebi:EbC_00060)

MetaCyc: 86% identical to K+:H+ symporter Kup (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-3

Predicted SEED Role

"Kup system potassium uptake protein" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (622 amino acids)

>IAI46_25080 low affinity potassium transporter Kup (Serratia liquefaciens MT49)
MSTEHKQSLSAVTLAAIGVVYGDIGTSPLYTLRECFSGHYGFDVRPDVVFGFLSLIFWML
IIIVSLKYLTYVMRADNAGEGGILTLMSLAGRNTSARTTAVLVILGLIGGSFFYGEVVIT
PAISVMSAIEGLEIAAPSLDGYIVPLSILVLTLLFAIQKHGTGSVGKLFAPVMLLWFIVL
AVLGARSIMANPEVLQALNPKWALNFFIEYKKVSFFALGAVVLSITGVEALYADMGHFGK
FPIRLAWFTVVLPSLVLNYFGQGALLLKNPEAIKNPFFLLAPDWALIPLLILATLATVIA
SQAVISGVFSLTRQAVRLGYLSPMRIIHTSEMESGQIYIPVINWTLYIAVVLVIVGFEHS
SNLAAAYGIAVTGTMVLTSILVTSVAIKNWHWNRFFAVGILVVLLIIDIPMFSANALKLF
SGGWLPLMLALVMFIIMTTWKSERFRLLRRMHEHGNSLEAMIASLEKSPPVRVPGTAVFM
SRAINVIPFALLHNLKHNKVLHERVVLLTLRTEDAPYVHNVRRVTIEQLSPTFWRVVASY
GWRETPNVEEVFHRCGLEGLPCRMTETSFFMSHESLILTKRPWYLFLRGKLFIALSRNAL
RAPDQFEIPPNRVIELGTQVEI