Protein Info for IAI46_24915 in Serratia liquefaciens MT49

Annotation: NCS2 family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 transmembrane" amino acids 39 to 64 (26 residues), see Phobius details amino acids 71 to 90 (20 residues), see Phobius details amino acids 100 to 101 (2 residues), see Phobius details amino acids 106 to 106 (1 residues), see Phobius details amino acids 129 to 148 (20 residues), see Phobius details amino acids 159 to 182 (24 residues), see Phobius details amino acids 194 to 213 (20 residues), see Phobius details amino acids 220 to 241 (22 residues), see Phobius details amino acids 261 to 281 (21 residues), see Phobius details amino acids 351 to 373 (23 residues), see Phobius details amino acids 380 to 400 (21 residues), see Phobius details amino acids 409 to 430 (22 residues), see Phobius details amino acids 439 to 459 (21 residues), see Phobius details TIGR00801: uracil-xanthine permease" amino acids 30 to 458 (429 residues), 458.9 bits, see alignment E=8.4e-142 PF00860: Xan_ur_permease" amino acids 35 to 427 (393 residues), 365.7 bits, see alignment E=1.2e-113

Best Hits

Swiss-Prot: 86% identical to XANP_ECOLI: Xanthine permease XanP (xanP) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 97% identity to spe:Spro_4873)

MetaCyc: 86% identical to xanthine:H+ symporter XanP (Escherichia coli K-12 substr. MG1655)
RXN-5076

Predicted SEED Role

"Xanthine permease" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (466 amino acids)

>IAI46_24915 NCS2 family protein (Serratia liquefaciens MT49)
MTQPSAEFDAAQKASATPRNSELIYRLEDRPPLPQTLFAAGQHLLAMFVAVITPALLICQ
ALGLPAQDTQHIISMSLFASGLASILQIKTWGPVGSGLLSIQGTSFNFVSPLIMGGLALK
NGGADVPTMMAALFGTLMVASCTEILLSRVLHLARRIITPLVSGIVVMIIGLSLIQVGLT
SIGGGYAAMNGGTFGAPKNLLLAGAVLLVIILLNRQRNPYLRVASLVIAMAVGYLLAWAM
GMLPESQPTPETAAIIIPTPLYYGLGFDWNLLLPLMLIFMVTSLETIGDITATSDVSEQP
VSGPLYMKRLKGGVLANGLNSMLSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALML
IALGLFPAVAGFVQHIPEPVLGGATLVMFGTIAASGVRIVSRERLNRRAIMIMALSLAVG
MGVSQQPLILQFAPDWLKTLLSSGIAAGGITAIVLNLLFPQEHEKQ