Protein Info for IAI46_24575 in Serratia liquefaciens MT49

Annotation: HslU--HslV peptidase ATPase subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 444 TIGR00390: ATP-dependent protease HslVU, ATPase subunit" amino acids 4 to 444 (441 residues), 764.9 bits, see alignment E=1.3e-234 PF07728: AAA_5" amino acids 52 to 88 (37 residues), 25.2 bits, see alignment 3.6e-09 PF00004: AAA" amino acids 53 to 136 (84 residues), 33.6 bits, see alignment E=1.2e-11 amino acids 240 to 333 (94 residues), 29.8 bits, see alignment E=1.9e-10 PF07724: AAA_2" amino acids 187 to 330 (144 residues), 96.8 bits, see alignment E=3.6e-31

Best Hits

Swiss-Prot: 99% identical to HSLU_SERP5: ATP-dependent protease ATPase subunit HslU (hslU) from Serratia proteamaculans (strain 568)

KEGG orthology group: K03667, ATP-dependent HslUV protease ATP-binding subunit HslU (inferred from 99% identity to spe:Spro_4793)

MetaCyc: 90% identical to ATPase component of the HslVU protease (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"ATP-dependent hsl protease ATP-binding subunit HslU" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (444 amino acids)

>IAI46_24575 HslU--HslV peptidase ATPase subunit (Serratia liquefaciens MT49)
MPEMTPREIVSELDSYIIGQNKAKRAVAIALRNRWRRMQLNEMLRHEVTPKNILMIGPTG
VGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAIKMVRLQSIDKNR
TRAEELAEERILDVLIPPAKNNWGQAEEHQEPSAARQAFRKKLREGQLDDKEIEIDLAAA
PMGVEIMAPPGMEEMTNQLQSMFQNLGGQKQKPRKLKIKEAFKLLVEEEAAKLVNPEELK
EQAIEAVEQHGIVFIDEIDKICKRGGQSSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKT
DHILFIASGAFQTASPSDLIPELQGRLPIRVELQALTTEDFERILTEPSASLTEQYKALM
GTEGVNIDFTADGIRRIAEAAWQVNESTENIGARRLHTVLERLMEDISYDASEINGQSIT
IDADYVRNHLDELVADEDLSRFIL