Protein Info for IAI46_24520 in Serratia liquefaciens MT49

Annotation: acetylornithine deacetylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01892: acetylornithine deacetylase (ArgE)
  • amino acids 8 to 375 (368 residues), 513.8 bits, E=1.3e-158
• PF04389: Peptidase_M28
  • amino acids 61 to 155 (95 residues), 22 bits, E=1.8e-08
• PF01546: Peptidase_M20
  • amino acids 74 to 376 (303 residues), 119.7 bits, E=2.6e-38
• PF07687: M20_dimer
  • amino acids 176 to 283 (108 residues), 85.2 bits, E=4.3e-28

Best Hits

Swiss-Prot: 86% identical to ARGE_YERPE: Acetylornithine deacetylase (argE) from Yersinia pestis

KEGG orthology group: K01438, acetylornithine deacetylase [EC: 3.5.1.16] (inferred from 98% identity to spe:Spro_4782)

MetaCyc: 76% identical to acetylornithine deacetylase (Escherichia coli K-12 substr. MG1655)
Acetylornithine deacetylase. [EC: 3.5.1.16]

Predicted SEED Role

"Acetylornithine deacetylase (EC 3.5.1.16)" in subsystem Arginine Biosynthesis extended (EC 3.5.1.16)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (17/17 steps found)
• L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
• L-ornithine biosynthesis I (5/5 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.16

Use Curated BLAST to search for 3.5.1.16

Protein Sequence (381 amino acids)

>IAI46_24520 acetylornithine deacetylase (Serratia liquefaciens MT49)
MKLPPFIELYRALIATPSISATDGALDQSNEALINLLAGWFADLGFRVDVQPVPDSRNKF
NLLASIGEGSGGLLLAGHTDTVPYDEGRWTRDPFTLTEHDNKLYGLGTADMKGFFAFILD
AVRDIDASQLTKPLYILATADEETTMAGARYFAASTSIRPDFAIIGEPTSLQPVRAHKGH
MANAIRIVGQSGHSSDPARGVNAIDLMHDTIGRLMELRKTLQERYNNPAFAVPYPTMNFG
HISGGDAANRICACCELHLDIRPLPGMTLDNINELMHQTLEPISQRWPGRLSIEELHASV
PGYECPTDHQMVAVIEKLLGTRTQVVNYCTEAPFVQQVCPTLVLGPGSIDQAHQPDEYID
TGFIEPTRKLLGQLVDHFCRQ