Protein Info for IAI46_24500 in Serratia liquefaciens MT49

Annotation: argininosuccinate lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00838: argininosuccinate lyase
  • amino acids 3 to 456 (454 residues), 699.6 bits, E=1e-214
• PF00206: Lyase_1
  • amino acids 6 to 301 (296 residues), 331.9 bits, E=4.5e-103
• PF14698: ASL_C2
  • amino acids 364 to 431 (68 residues), 90.5 bits, E=7.7e-30

Best Hits

Swiss-Prot: 98% identical to ARLY_SERP5: Argininosuccinate lyase (argH) from Serratia proteamaculans (strain 568)

KEGG orthology group: None (inferred from 99% identity to srr:SerAS9_4872)

MetaCyc: 88% identical to argininosuccinate lyase (Escherichia coli K-12 substr. MG1655)
Argininosuccinate lyase. [EC: 4.3.2.1]

Predicted SEED Role

"Argininosuccinate lyase (EC 4.3.2.1)" in subsystem Arginine Biosynthesis extended (EC 4.3.2.1)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (17/17 steps found)
• L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
• L-arginine biosynthesis II (acetyl cycle) (9/10 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
• urea cycle (4/5 steps found)
• superpathway of L-citrulline metabolism (9/12 steps found)
• nitric oxide biosynthesis II (mammals) (2/3 steps found)
• canavanine biosynthesis (2/4 steps found)
• L-arginine biosynthesis IV (archaea) (4/9 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.2.1

Protein Sequence (457 amino acids)

>IAI46_24500 argininosuccinate lyase (Serratia liquefaciens MT49)
MALWGGRFSQAADQRFKQLNDSLRFDYRLAEQDIVGSVAWSKALVTVNVLTATEQQQLEQ
ALSVLLEEVQADPQAIVSSDAEDIHSWVEQKLIDKVGDLGKKLHTGRSRNDQVATDLKLW
CKHQIGELHQAIVQLQQALVETAEANQDAVMPGYTHLQRAQPVTFAHWCLAYVEMLARDE
SRLQDTLKRLDVSPLGSGALAGTAYPIDREQLAGWLGFASATRNSLDSVSDRDHVLELLS
NASISMVHLSRFAEDLIFFNSGEAAFVDLSDRVTSGSSLMPQKKNPDALELIRGKCGRVQ
GALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWMDCLQMAALVLDGIQVKRPRCKEAA
EQGYANSTELADYLVAKGVPFREAHHIVGEAVVEAIRQGKALEALPLADLQKFSAVIGDD
VYPILALQSCLDKRSAKGGVSPQQVASAIAAAKQRLA