Protein Info for IAI46_24330 in Serratia liquefaciens MT49

Annotation: HTH-type transcriptional activator IlvY

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 299 transmembrane" amino acids 218 to 245 (28 residues), see Phobius details PF00126: HTH_1" amino acids 3 to 62 (60 residues), 77.6 bits, see alignment E=8.5e-26 PF03466: LysR_substrate" amino acids 89 to 295 (207 residues), 127.3 bits, see alignment E=8.6e-41

Best Hits

Swiss-Prot: 74% identical to ILVY_ECOLI: HTH-type transcriptional regulator IlvY (ilvY) from Escherichia coli (strain K12)

KEGG orthology group: K02521, LysR family transcriptional regulator, positive regulator for ilvC (inferred from 100% identity to spe:Spro_4752)

Predicted SEED Role

"HTH-type transcriptional regulator IlvY" in subsystem Alanine biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (299 amino acids)

>IAI46_24330 HTH-type transcriptional activator IlvY (Serratia liquefaciens MT49)
MDLRDLKLFLHLAESHHFGRTAKAMHVSPSTLSRQIQRLEEILGQPLFLRDNRTVQLTDA
GEQLKDFAQQTLLQYQQLKHSLGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRAQHPLV
EIKLTTGDAADAVDKVQSNEADLGIAGRPETLPTSVAFTKIGEIPLVLIAPALPCAVRSQ
AFAEQPDWANIPFILPEHGPSRKRIELWFRRQRIANPLIYATVGGHEAIVSMVALGCGIA
LIPGVVVDNSPEPVRNRISQLENISMVEPFELGVCVQKKRLSDPLIDAFWRLLLTVKNP