Protein Info for IAI46_23965 in Serratia liquefaciens MT49

Annotation: gluconate operon transcriptional repressor GntR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 331 PF00356: LacI" amino acids 8 to 52 (45 residues), 57.7 bits, see alignment 1.6e-19 PF00532: Peripla_BP_1" amino acids 64 to 314 (251 residues), 104.8 bits, see alignment E=1.2e-33 PF13407: Peripla_BP_4" amino acids 66 to 276 (211 residues), 42.3 bits, see alignment E=1.4e-14 PF13377: Peripla_BP_3" amino acids 173 to 330 (158 residues), 90 bits, see alignment E=4e-29

Best Hits

Swiss-Prot: 80% identical to GNTR_ECOL6: HTH-type transcriptional regulator GntR (gntR) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K06145, LacI family transcriptional regulator, gluconate utilization system Gnt-I transcriptional repressor (inferred from 98% identity to spe:Spro_4652)

Predicted SEED Role

"Gluconate utilization system Gnt-I transcriptional repressor" in subsystem D-gluconate and ketogluconates metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (331 amino acids)

>IAI46_23965 gluconate operon transcriptional repressor GntR (Serratia liquefaciens MT49)
MKKKRPVLQDVADKVGVTKMTVSRYLRNPEQVSAILQQKIAVALDELGYIPNRAPDILSN
STSRAIGVLLPSLTNQVFAEVLRGIESVTDAHNYQTMLAHYGYLPEREEQRLTSLLSYNI
DGLILSERHHTPRTMKMIEVAGIPVVELMDCVSPCIDLAVGFNNFEAARQMTQQIIAHGH
RHVVYFGARQDERTIIKLQGYEQAMRESGLEPYSVMTARSSSYSAGGELLRQAQRDYPQI
DSIFCTNDDLAIGATFECQRQGLSIPKDMAIAGFHGHDIGQVMVPKLASVLTPRERMGQI
GAERLLARLRGETVSPRMVDVGFTVIPGGSI