Protein Info for IAI46_23590 in Serratia liquefaciens MT49
Annotation: aspartate aminotransferase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 86% identical to ARGD_YERPE: Acetylornithine/succinyldiaminopimelate aminotransferase (argD) from Yersinia pestis
KEGG orthology group: K00821, acetylornithine/N-succinyldiaminopimelate aminotransferase [EC: 2.6.1.11 2.6.1.17] (inferred from 96% identity to spe:Spro_4582)MetaCyc: 76% identical to N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase (Escherichia coli K-12 substr. MG1655)
Succinyldiaminopimelate transaminase. [EC: 2.6.1.17]; Acetylornithine transaminase. [EC: 2.6.1.17, 2.6.1.11]
Predicted SEED Role
"Acetylornithine aminotransferase (EC 2.6.1.11) / N-succinyl-L,L-diaminopimelate aminotransferase (EC 2.6.1.17)" in subsystem Arginine Biosynthesis extended or Lysine Biosynthesis DAP Pathway (EC 2.6.1.11, EC 2.6.1.17)
MetaCyc Pathways
- aspartate superpathway (25/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
- superpathway of arginine and polyamine biosynthesis (17/17 steps found)
- L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
- L-lysine biosynthesis I (9/9 steps found)
- L-arginine biosynthesis II (acetyl cycle) (9/10 steps found)
- L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
- L-ornithine biosynthesis I (5/5 steps found)
KEGG Metabolic Maps
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Lysine biosynthesis
- Urea cycle and metabolism of amino groups
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.6.1.11 or 2.6.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (405 amino acids)
>IAI46_23590 aspartate aminotransferase family protein (Serratia liquefaciens MT49) MTEKSAVTRSTFDQVILPVYAPAQFVPVRGKGSRVWDQQGKEYIDFSGGIAVTALGHCHP ALVEALKQQGETLWHTSNVFTNEPALRLATKLINATFADRVFFANSGAEANEAAFKLARH YAITRHSPYKTKIIAFYNAFHGRTLFTVSVGGQAKYSDGFGPKPADIVHVPFNDLAAVKA VMDDHTCAVVMEPIQGEGGITPVDADFLKGVRELCDQHQALLVFDEVQSGMGRSGKLFAY MHYGVTPDILTTAKALGGGFPVSAMLTTEEIASVMQVGTHGTTYGGNPLACAVAEAALDV INTPEVLSGIELRHGLYVQALKQIGEKYGVFSDIRGMGLLIGAELTKNHHGKARDFLTAA AARGLMILNAGPNVIRFAPSLVVATEDIDEGMALFELAVQDVIGA