Protein Info for IAI46_23495 in Serratia liquefaciens MT49

Annotation: FKBP-type peptidyl-prolyl cis-trans isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 277 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF01346: FKBP_N" amino acids 52 to 158 (107 residues), 77.2 bits, see alignment E=1.5e-25 PF00254: FKBP_C" amino acids 166 to 252 (87 residues), 107 bits, see alignment E=5.3e-35

Best Hits

Swiss-Prot: 78% identical to FKBA_ECOLI: FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (fkpA) from Escherichia coli (strain K12)

KEGG orthology group: K03772, FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC: 5.2.1.8] (inferred from 100% identity to spe:Spro_4556)

MetaCyc: 78% identical to peptidyl-prolyl cis-trans isomerase/OMP chaperone FkpA (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]

Predicted SEED Role

"FKBP-type peptidyl-prolyl cis-trans isomerase FkpA precursor (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase or Potassium homeostasis (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (277 amino acids)

>IAI46_23495 FKBP-type peptidyl-prolyl cis-trans isomerase (Serratia liquefaciens MT49)
MKSLFKVTLLATTMAFALNATQVMAADAAKPAEAAKAADAAPSTGKFKNDDEQAAYALGA
SLGRYMDNSLKEQEKLGIKLDKDQLISGVQDAFANKSKLNDADIEKTLQSFEARVKASAQ
AKMEQDAKDNEAKGTKYRDTFAKEKGVKKTESGLLYQVEKPGTGSAPKDSDTVVVNYKGT
LTDGTEFDNSYTRGEPLSFRLDGVIPGWTEGLKHIKKGGKIKLVIPPALAYGKTGVPGIP
ANSTLVFDVELLDVKAAPKADAKAEKPADAAADAKAQ