Protein Info for IAI46_23200 in Serratia liquefaciens MT49

Annotation: homoserine O-succinyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01001: homoserine O-succinyltransferase
  • amino acids 1 to 302 (302 residues), 526.7 bits, E=1e-162
• PF04204: HTS
  • amino acids 2 to 299 (298 residues), 445.6 bits, E=3.6e-138

Best Hits

Swiss-Prot: 98% identical to METAS_SERP5: Homoserine O-succinyltransferase (metAS) from Serratia proteamaculans (strain 568)

KEGG orthology group: K00651, homoserine O-succinyltransferase [EC: 2.3.1.46] (inferred from 98% identity to spe:Spro_4504)

MetaCyc: 82% identical to homoserine O-succinyltransferase (Escherichia coli K-12 substr. MG1655)
Homoserine O-succinyltransferase. [EC: 2.3.1.46]

Predicted SEED Role

"Homoserine O-succinyltransferase (EC 2.3.1.46)" in subsystem Methionine Biosynthesis (EC 2.3.1.46)

MetaCyc Pathways

• aspartate superpathway (25/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (9/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (9/9 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (8/8 steps found)
• L-methionine biosynthesis I (5/5 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Methionine metabolism
• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.46

Protein Sequence (309 amino acids)

>IAI46_23200 homoserine O-succinyltransferase (Serratia liquefaciens MT49)
MPIRVPDELPAVSFLRNENVFVMTSSRAKTQEIRPLKVLILNLMPKKIETENQFLRLLSN
SSLQIDIQLLRIDSRESKNTPAEHLNNFYCDFEDIQDQNFDGLIVTGAPLGLVDFCDVAY
WPQIERVIDWAKNHVTSTLFVCWAVQAALNILYGIPKMTREVKLSGVYQHQTLQQHALLT
RGFDETFLAPHSRYADFPTEIIRQYTDLDILAESEQTGAYLFASKDKRLAFVTGHPEYDA
LTLAGEYCRDNEAGLNPVVPLNYFPDDNPELTPKATWRSHGHLLFANWLNYYVYQITPYD
LRHMNPTLE