Protein Info for IAI46_23115 in Serratia liquefaciens MT49

Annotation: hemagglutinin repeat-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1615 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details PF05860: TPS" amino acids 35 to 290 (256 residues), 135.7 bits, see alignment E=2.8e-43 TIGR01901: filamentous hemagglutinin family N-terminal domain" amino acids 66 to 159 (94 residues), 61.4 bits, see alignment 3.1e-21 PF13332: Fil_haemagg_2" amino acids 402 to 463 (62 residues), 31 bits, see alignment (E = 2.6e-11) amino acids 480 to 599 (120 residues), 16.4 bits, see alignment 8.4e-07 amino acids 631 to 791 (161 residues), 54.1 bits, see alignment E=2.2e-18 amino acids 813 to 897 (85 residues), 21.7 bits, see alignment 1.9e-08 amino acids 931 to 1091 (161 residues), 48 bits, see alignment E=1.6e-16 amino acids 1076 to 1184 (109 residues), 37.9 bits, see alignment 2.1e-13 amino acids 1116 to 1210 (95 residues), 31.1 bits, see alignment 2.5e-11 amino acids 1218 to 1382 (165 residues), 77 bits, see alignment E=1.9e-25

Best Hits

Swiss-Prot: 71% identical to HLYA_SERMA: Hemolysin (shlA) from Serratia marcescens

KEGG orthology group: K11016, hemolysin (inferred from 86% identity to spe:Spro_4482)

Predicted SEED Role

"Putative haemolysin/cytolysin secreted via TPS pathway"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1615 amino acids)

>IAI46_23115 hemagglutinin repeat-containing protein (Serratia liquefaciens MT49)
MKNNNFRLSGAGKLAASLAIILASLGSAYAGEIVAANGANGPGVSTAGNGAQVVNIVTPN
DHGLSHNQYQDFNVNQPGAVLNNSLDAGRSQLAGQLAANPNLNNQAASVILNEVISRNPS
LLHGQQEIFGMAADYVLANPNGISCDGCGFINTSRSSLVVGNPLVENGMLQGYSTLGNRN
TLSLDGRLNASGVLDLIAPRINSRGEVIVAPLYDKKSDKMISAINAISGNNRVSRDAQVL
SSEQPELTVWDQLLGTTDSYYLGSMQAGRINIIHTVTGSGVKLAGKLDGSDEIRVKAYNI
RTDSQVNDSSSNRNSGENYQNYRGGIYINDRSTGQQLARTELKGKNISLVADNSNHLTAT
DVRGEEITLQGASLTLDGQQLKQTQGHTDEQWFYSWKYNVTRENEQLQQATSNIEATKNA
TLIATEQDVTLRGAKVSAGNALNIDAKRDVQLSGLIEREKTSERGNQRNHTSSLRTGSWS
NSNETESLKSSSVFSGGDLAIKAGNRVVGQGTKVYASGDLKVDANDQINIGVQKTANEKT
VRDNKTSWGGIGGGNNQDNSNRREVSNASQVTADGTLWLNGKQGVTITGSTVKGAKGGFV
AATDGGLRIDNALSTTVDKVDARTGTVFNITSSSQKSNNSHQQSTASELVSDTNLQLVSK
KDTDVVGSKVTSTGKLEVNAGGNINVSSGEQQQHIDEQKTALAINGYANEKSDKQYRAGL
RIEHTSDSEKTTRSEQQSSTLSGGSVALKADKDVTFSGSKLVTTQGDASISGDNVAFLAA
DNKTTSDTEKTKIGGGVYYTGGIDKVGSGIEGGYENSKTHSQSSKTVTSGSDIAGNLTIN
AKDKLTQQGAQHQVGGKYQENANSVDHLAAVNSESSNTTKTDVGVDIGANVDYSAVTRPV
ERAVGKVAKLDANGVINEIGGIGAPNIGLDIGANGGSSEKSNSSSQAVVSKITAGSIDVK
ASGKLQDTGTQYQATQGSVALTADSHHSEAAKNSQQESSSETRGGASVRVYTTTGSDLTV
DAKGEGGNKHSESTGSQAVTGSITAANGIDIKVKQDAVYQGTSLEAGDGKAKVKAEDGNI
RFDQATDSSHESHNGFNVKVSAKGGTTPETKSFGLGLGGGYSNGKSDGSSAQVSNIGGKQ
GVELDAGRGLTLQGSNVTSQGDVSLKAGDKVALQAAQSQQTRKDDTLSGNIDIGGNSTDN
DKKSAGGLSLGGAFDIAKVDETSTTQQGGKITSGGAVTITAKGNDAHALHLQGTEVKGSS
VGLNAENGGVVLESVQNQEQKNNWNLGLKANAKGGQSFNKDANGKVDTTSGSDTHTLGAG
VKVGVDNLQKTTQGNSLISAGEVTINSGKDTQLAGARIDADSVQGNIGGDLRVESRKDSE
SSVKVDVDVGLSHTNDPASSITSKLSKVGTPHYAGKVKEKLEGGINKVADATTDKYNSVA
RRLDPKQDTTGAVSFSKAEGKVTLPETLVGEKEKGPLWDRGARFLGNKSKESLTGPAGLQ
GQFKVKADVVNNDAVGVQSAINGKNDVALNVQGTTRLTGGEIRSQQGEVALGNGKLEQQD
VAGNRYQGGGHLDAAASAGALLGIAGKSVVNLETPVGGYINNQATDAKAGVFSGK