Protein Info for IAI46_22840 in Serratia liquefaciens MT49

Annotation: NCS2 family permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 453 transmembrane" amino acids 33 to 53 (21 residues), see Phobius details amino acids 60 to 81 (22 residues), see Phobius details amino acids 87 to 106 (20 residues), see Phobius details amino acids 113 to 137 (25 residues), see Phobius details amino acids 145 to 169 (25 residues), see Phobius details amino acids 176 to 201 (26 residues), see Phobius details amino acids 208 to 228 (21 residues), see Phobius details amino acids 248 to 274 (27 residues), see Phobius details amino acids 307 to 325 (19 residues), see Phobius details amino acids 337 to 354 (18 residues), see Phobius details amino acids 361 to 381 (21 residues), see Phobius details amino acids 393 to 421 (29 residues), see Phobius details amino acids 432 to 452 (21 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 30 to 413 (384 residues), 283.3 bits, see alignment E=1.3e-88

Best Hits

Swiss-Prot: 87% identical to GHXQ_ECOLI: Guanine/hypoxanthine permease GhxQ (ghxQ) from Escherichia coli (strain K12)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 98% identity to spe:Spro_4431)

MetaCyc: 87% identical to guanine/hypoxanthine transporter GhxQ (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-562; TRANS-RXN0-578

Predicted SEED Role

"Guanine-hypoxanthine permease" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (453 amino acids)

>IAI46_22840 NCS2 family permease (Serratia liquefaciens MT49)
MSNSQANNAVKPKGGLDGYFNISARGSTVRQEVVAGLTTFLAMVYSVIVVPSMLGKAGFP
PTAVFVATCLVAGLGSLLMGLWANLPMAIGCAISLTAFTAFSLVLGQHISIPVALGAVFL
MGVLFTIISVTGIRAWILRNLPMGVAHGTGIGIGLFLLLIAANGVGLVVKNPLDGLPVAL
GAFTSFPVVMTLLGLAVIFGLEKLRVPGGILLVIITISVVGLVFDPAVKYQGLFAMPSLA
DANGNSLIFSLDIMGALQPVVLPSVLALVMTAVFDATGTIRAVAGQANLLDKDGQIINGG
KALTSDSLSSIFSGLVGAAPAAVYIESAAGTAAGGKTGLTATVVGLLFLLILFLSPLSYL
VPVYATAPALMYVGLLMLSNVTKLDFNDFVDAMSGLLCAVFIVLTCNIVTGIMLGFSSLV
IGRIFSGEWRRLNIGTVLIAVALVAFYAGGWAI