Protein Info for IAI46_22765 in Serratia liquefaciens MT49

Annotation: sodium/pantothenate symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 481 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 45 to 64 (20 residues), see Phobius details amino acids 74 to 94 (21 residues), see Phobius details amino acids 122 to 144 (23 residues), see Phobius details amino acids 158 to 178 (21 residues), see Phobius details amino acids 190 to 212 (23 residues), see Phobius details amino acids 234 to 253 (20 residues), see Phobius details amino acids 273 to 294 (22 residues), see Phobius details amino acids 313 to 335 (23 residues), see Phobius details amino acids 368 to 386 (19 residues), see Phobius details amino acids 392 to 416 (25 residues), see Phobius details amino acids 424 to 444 (21 residues), see Phobius details amino acids 451 to 469 (19 residues), see Phobius details TIGR02119: sodium/pantothenate symporter" amino acids 4 to 472 (469 residues), 776.6 bits, see alignment E=1.1e-237 PF00474: SSF" amino acids 36 to 432 (397 residues), 452.4 bits, see alignment E=7e-140 TIGR00813: transporter, solute:sodium symporter (SSS) family" amino acids 36 to 432 (397 residues), 365.3 bits, see alignment E=4.7e-113

Best Hits

Swiss-Prot: 83% identical to PANF_ECOLI: Sodium/pantothenate symporter (panF) from Escherichia coli (strain K12)

KEGG orthology group: K14392, sodium/pantothenate symporter (inferred from 98% identity to spe:Spro_4420)

MetaCyc: 83% identical to pantothenate:Na+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-117

Predicted SEED Role

"Pantothenate:Na+ symporter (TC 2.A.21.1.1)" in subsystem Coenzyme A Biosynthesis (TC 2.A.21.1.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (481 amino acids)

>IAI46_22765 sodium/pantothenate symporter (Serratia liquefaciens MT49)
MQTEVILPLVAYLVLVFGLSVYAYSRRQSGNFLSEYFLGNRSMGGFVLAMTLTATYISAS
SFIGGPGAAYKYGLGWVLLAMIQLPAVWLSLGVLGKKFAILARRYNAITLNDMLYGRYQS
RLLVWLASLSLLVAFLGAMTVQFIGGARLLETAAGIPYDTGLLIFGISIALYTAFGGFRA
SVLNDAMQGLVMLIGTVLLLVAVIHAAGGLHSAVDKLQQIDPALVSPQGGEQILSLPFMA
SFWILVCFGVIGLPHTAVRCISYKDSKAVHRGIILGTMVVAVLMFGMHLAGALGRAVLPD
LKIPDQVIPTLMITVLPPYAAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLGVRPQHM
QNERLIKRFSSLTTLILGLLVLLAAWRPPEMIIWLNLLAFGGLEAVFLWPLVLGLYWERA
NAQGALSSMVTGAVCYTLLASFNLQLAGLHPIVPSLLLSLLAFYIGNVIGEKRRVASSLA
S