Protein Info for IAI46_22335 in Serratia liquefaciens MT49

Annotation: aerobic respiration two-component sensor histidine kinase ArcB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 779 transmembrane" amino acids 20 to 46 (27 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details PF18415: HKR_ArcB_TM" amino acids 15 to 88 (74 residues), 103.2 bits, see alignment E=3.8e-33 TIGR00229: PAS domain S-box protein" amino acids 153 to 276 (124 residues), 48.8 bits, see alignment E=3.7e-17 PF00989: PAS" amino acids 156 to 266 (111 residues), 65.1 bits, see alignment E=2e-21 PF08448: PAS_4" amino acids 161 to 271 (111 residues), 58.9 bits, see alignment E=2e-19 PF00512: HisKA" amino acids 283 to 345 (63 residues), 61.7 bits, see alignment 1.9e-20 PF02518: HATPase_c" amino acids 395 to 505 (111 residues), 101.7 bits, see alignment E=1.2e-32 PF00072: Response_reg" amino acids 528 to 639 (112 residues), 78.7 bits, see alignment E=1.3e-25 PF01627: Hpt" amino acids 686 to 771 (86 residues), 55.9 bits, see alignment E=1.5e-18

Best Hits

Swiss-Prot: 81% identical to ARCB_ECO57: Aerobic respiration control sensor protein ArcB (arcB) from Escherichia coli O157:H7

KEGG orthology group: K07648, two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC: 2.7.13.3] (inferred from 82% identity to ebi:EbC_40450)

MetaCyc: 81% identical to sensor histidine kinase ArcB (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Aerobic respiration control sensor protein arcB (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (779 amino acids)

>IAI46_22335 aerobic respiration two-component sensor histidine kinase ArcB (Serratia liquefaciens MT49)
MKQIRVLAQYYVDLMVKLGLVRFSLLLASALVVLAMVVQMAVTMLLRGEVESIDVVRSIF
FGLLITPWAVYFLSVVVEQLEESRQRLARLVDKLEEMRHRDLELNQQLKDNISQLNQEIA
DRIKAEEERQQVMDKLTEEMEQRELAQIELGQQSALLRSFLDASPDLVYYRNEDKEFSGC
NRAMELLTGKSEKQLIGLTPYDVYGQEIAEKVIETDEKVFRHNVSLTYEQWLVYPDGRKA
CFELRKVPFYDRVGKRHGLMGFGRDITERKRYQDALENASRDKTTFISTISHELRTPLNG
IVGLSRILLDTELNDEQLKYLKTIHVSAITLGNIFNDIIEMDKLERRKVQLDNQPVDFTG
FLADLENLSGLLAQPKGLQFVMEPQQPLPQQIITDGTRLRQILWNLIGNAVKFTPQGQIV
VRVRREEQDRLVFEVEDSGMGIPKDEQDKIFAMYYQVKDQHGGRPATGTGIGLAVSKRLA
QSMGGDITVNSVQGHGSCFTLTIQAPAVKEAESETQAEEALPLPALHILLVEDIELNVIV
ARSVLEKLGNSVEVAMNGKDALAMFDPDEFDLVLLDIQLPDMTGLDIARVLRERYAGQAL
PPLVALTANVLKDKKEYLDAGMDDVLSKPLSVPALTKVIKHYWDHQPSHTTKKMEQKTMQ
INESLLDTTMLEQYMDLVGPQLIHQSLEMFEQMMPGYLAVLDSNMTARDQKGITEEGHKI
KGAAGSVGLRHLQQLAQQIQTPTLPAWWDNVQDWVDELKQEWRNDVQVLRAWVAEAEKK