Protein Info for IAI46_22085 in Serratia liquefaciens MT49

Annotation: bifunctional dihydroneopterin aldolase/7,8-dihydroneopterin epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00526: FolB domain
  • amino acids 1 to 116 (116 residues), 137.6 bits, E=2.4e-44
• PF02152: FolB
  • amino acids 4 to 113 (110 residues), 114 bits, E=2.8e-37
• TIGR00525: dihydroneopterin aldolase
  • amino acids 4 to 114 (111 residues), 94.7 bits, E=5.4e-31

Best Hits

Swiss-Prot: 79% identical to FOLB_ECOLI: Dihydroneopterin aldolase (folB) from Escherichia coli (strain K12)

KEGG orthology group: K01633, dihydroneopterin aldolase [EC: 4.1.2.25] (inferred from 99% identity to srs:SerAS12_4404)

MetaCyc: 79% identical to dihydroneopterin aldolase (Escherichia coli K-12 substr. MG1655)
RXN-10856 [EC: 5.1.99.8]; Dihydroneopterin aldolase. [EC: 5.1.99.8, 4.1.2.25]

Predicted SEED Role

"Dihydroneopterin aldolase (EC 4.1.2.25)" in subsystem Folate Biosynthesis (EC 4.1.2.25)

MetaCyc Pathways

• superpathway of chorismate metabolism (54/59 steps found)
• superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
• superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I (4/5 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia) (3/5 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus) (2/7 steps found)
• tetrahydromethanopterin biosynthesis (3/14 steps found)

KEGG Metabolic Maps

• Folate biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.25 or 5.1.99.8

Protein Sequence (119 amino acids)

>IAI46_22085 bifunctional dihydroneopterin aldolase/7,8-dihydroneopterin epimerase (Serratia liquefaciens MT49)
MDIVFIEELTVITTIGVYAWEQNIRQKLVFDIEMGWDNRQAAASDDVNDCLSYADISEAI
IQHVEPNRFALVERVAEEISEILLQRFNSPWVRIKVSKPGAVAHASRVGVIIERGTRPV