Protein Info for IAI46_22050 in Serratia liquefaciens MT49

Annotation: L-methionine/branched-chain amino acid transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 417 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details transmembrane" amino acids 43 to 63 (21 residues), see Phobius details amino acids 89 to 111 (23 residues), see Phobius details amino acids 117 to 137 (21 residues), see Phobius details amino acids 148 to 166 (19 residues), see Phobius details amino acids 186 to 208 (23 residues), see Phobius details amino acids 220 to 243 (24 residues), see Phobius details amino acids 266 to 286 (21 residues), see Phobius details amino acids 316 to 336 (21 residues), see Phobius details amino acids 343 to 363 (21 residues), see Phobius details amino acids 374 to 406 (33 residues), see Phobius details PF13520: AA_permease_2" amino acids 8 to 387 (380 residues), 104.9 bits, see alignment E=5.2e-34 PF00324: AA_permease" amino acids 22 to 407 (386 residues), 59.9 bits, see alignment E=2e-20

Best Hits

Swiss-Prot: 72% identical to YJEH_ECOLI: L-methionine/branched-chain amino acid exporter YjeH (yjeH) from Escherichia coli (strain K12)

KEGG orthology group: K03294, basic amino acid/polyamine antiporter, APA family (inferred from 94% identity to srs:SerAS12_4397)

MetaCyc: 72% identical to L-methionine/branched chain amino acid exporter (Escherichia coli K-12 substr. MG1655)
RXN0-7050; TRANS-RXN-281; TRANS-RXN-282; TRANS-RXN0-270

Predicted SEED Role

"Putative permease"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (417 amino acids)

>IAI46_22050 L-methionine/branched-chain amino acid transporter (Serratia liquefaciens MT49)
MSGLKQELSLAQGVGLLSTSLLGTGVFAVPALAAQVAQGDSLWAWPVLIALVFPIAIAFA
ALGRHFPSAGGAAHFVGLAFGPRMAKVTGWLFLSVIPVGLPAALQIAAGFWQAAFGWNAN
GLLLVQIATLMVIWLLGTRSAGSSANIQTLIAMLVVALVAAIWWRGGISPAQIPWPALDE
ISPPNLFHALAVMFWCFVGLEAFAHLATEFRNPERDFPRALLFGLLVAGAVYWGCTVAVL
HFHAYSEHQAAAASLPGIVVQLFGQHALWVACVIGYLACFASVNIYTQSFARLVWSQAQD
RPASALAKLSAGQAPVNALSAVVGCCLLFTLLIYTLKLPLDMLLVYANGIFVLIYLLCML
AGCRILHGRSRLMAAVGLGLCLLLMVIIGWKSLYALGMFALIWLVLPRRPKAALKRQ