Protein Info for IAI46_21895 in Serratia liquefaciens MT49

Annotation: 1-acylglycerol-3-phosphate O-acyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00530: 1-acylglycerol-3-phosphate O-acyltransferases
  • amino acids 50 to 180 (131 residues), 160.6 bits, E=7.8e-52
• PF01553: Acyltransferase
  • amino acids 53 to 180 (128 residues), 129.3 bits, E=4.3e-42

Best Hits

Swiss-Prot: 77% identical to PLSC_ECOLI: 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC) from Escherichia coli (strain K12)

KEGG orthology group: K00655, 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC: 2.3.1.51] (inferred from 96% identity to srs:SerAS12_4374)

MetaCyc: 77% identical to 1-acylglycerol-3-phosphate O-acyltransferase PlsC (Escherichia coli K-12 substr. MG1655)
1-acylglycerol-3-phosphate O-acyltransferase. [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]; 2.3.1.51 [EC: 2.3.1.51]

Predicted SEED Role

"1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Phosphate metabolism (EC 2.3.1.51)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (11/12 steps found)
• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• CDP-diacylglycerol biosynthesis I (4/4 steps found)
• CDP-diacylglycerol biosynthesis II (4/4 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• oleate biosynthesis III (cyanobacteria) (2/3 steps found)
• palmitoleate biosynthesis III (cyanobacteria) (1/2 steps found)
• phospholipid remodeling (phosphatidate, yeast) (1/2 steps found)
• CDP-diacylglycerol biosynthesis III (3/5 steps found)
• phosphatidate biosynthesis (yeast) (3/5 steps found)
• diacylglycerol and triacylglycerol biosynthesis (3/7 steps found)
• palmitoyl ethanolamide biosynthesis (2/6 steps found)
• superpathway of stearidonate biosynthesis (cyanobacteria) (2/6 steps found)
• stigma estolide biosynthesis (2/7 steps found)
• anandamide biosynthesis II (2/8 steps found)
• anandamide biosynthesis I (4/12 steps found)
• plasmalogen biosynthesis I (aerobic) (2/16 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerolipid metabolism
• Glycerophospholipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.51

Use Curated BLAST to search for 2.3.1.51

Protein Sequence (244 amino acids)

>IAI46_21895 1-acylglycerol-3-phosphate O-acyltransferase (Serratia liquefaciens MT49)
MLLILRAILATLYCILVCIFGSIYCLFSPRDPRHVATFGHLFGRLSGLFGLKVEVRVPAD
AAKNGNCIYIANHQNNYDMVTAAKAVQPRTVTVGKKSLLWVPFFGPLYWLTGNLLIDRDN
RAKAHGTIAQVAEQFKKRDISIWMFPEGTRSRGRGLMPFKTGAFHAAIAAGVPIVPICVS
TTSGKINLNRWNNGHAIVEMLEPVDISGYGRENVRELAAHCHELMLVKIAELDAEVAQRN
AAGK