Protein Info for IAI46_21700 in Serratia liquefaciens MT49

Annotation: shikimate 5-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08501: Shikimate_dh_N
  • amino acids 25 to 93 (69 residues), 63.2 bits, E=1.1e-21

Best Hits

Swiss-Prot: 64% identical to SHDHL_HAEIN: Shikimate dehydrogenase-like protein HI_0607 (sdhL) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: None (inferred from 92% identity to srr:SerAS9_4352)

Predicted SEED Role

"Shikimate 5-dehydrogenase I gamma (EC 1.1.1.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 1.1.1.25)

MetaCyc Pathways

• superpathway of chorismate metabolism (54/59 steps found)
• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.25

Use Curated BLAST to search for 1.1.1.25

Protein Sequence (272 amino acids)

>IAI46_21700 shikimate 5-dehydrogenase (Serratia liquefaciens MT49)
MSREINKDTQLCMSLAGRPGNFGTRFHNYLYQELDLNFIYKAFTTQDIQAAVGGVRALGI
RGCAVSMPFKESCIPFLDELDASATAIESVNTIVNDAGFLRAYNTDYIAIAKLLAQYQIP
TETAFALRGSGGMAKAVTAALRDAGFKNGHIIARNPQAGQALASAYGYQWQAQVDELKVD
MVINVTPIGMAGGAEAEQLAFAPATVDAAKIVFDVVALPAETPLVRYGREHGKQVITGAE
VIALQALEQFVLYTGVRPTDEQIARAAAHARG