Protein Info for IAI46_21230 in Serratia liquefaciens MT49

Annotation: two-component system sensor histidine kinase QseC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 167 to 185 (19 residues), see Phobius details PF08521: 2CSK_N" amino acids 19 to 159 (141 residues), 23.4 bits, see alignment E=8e-09 PF00512: HisKA" amino acids 240 to 304 (65 residues), 47.7 bits, see alignment E=1.9e-16 PF02518: HATPase_c" amino acids 353 to 450 (98 residues), 80.4 bits, see alignment E=2.1e-26

Best Hits

Swiss-Prot: 57% identical to QSEC_ECO57: Sensor protein QseC (qseC) from Escherichia coli O157:H7

KEGG orthology group: K07645, two-component system, OmpR family, sensor histidine kinase QseC [EC: 2.7.13.3] (inferred from 94% identity to spe:Spro_3989)

Predicted SEED Role

"Sensory histidine kinase QseC" in subsystem Orphan regulatory proteins

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>IAI46_21230 two-component system sensor histidine kinase QseC (Serratia liquefaciens MT49)
MKHLSLRLRLILIFSLLALLTWCSASLVAWMMTRNNINEVFDTQQMLFAKRLATANLGDL
LADENARSLPKTKKLVHHGKRGEQDDDALAFAIFDRNGKMLLNDGENGADFLFDGEREGF
TDGERKGDDDSWRLLWLTSPDGRYRIVVGQEWDYRRDMALGMVTGQLVPWLVTLPILMLL
IALMVGRELKPLRTVAAGLRKRAPDDATPLDARQVPTEVRPLVDALNALFARINALLVRE
RRFTSDAAHELRSPLAALRVQTEVVQLAGDDEQMREHALENLTVSIDRATRLVDQLLTLS
RLDSLSDLAELEAVDWGQLVPMTLAEQDRHAHAAGVTLRYEQQGTPPPLQGQALLLSLLV
RNLVDNAVRYTPAGGTVTVKLTERMLRVEDDGPGVTEEHLTRLGERFYRPPGQEQTGSGL
GLSIVQRIASLHGLRVSFANRPEGGFVAQVVL