Protein Info for IAI46_21195 in Serratia liquefaciens MT49

Annotation: ATP-dependent helicase HrpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 812 TIGR01970: ATP-dependent helicase HrpB" amino acids 4 to 811 (808 residues), 1123.5 bits, see alignment E=0 PF00270: DEAD" amino acids 15 to 162 (148 residues), 50.4 bits, see alignment E=3.4e-17 PF00271: Helicase_C" amino acids 203 to 327 (125 residues), 49.3 bits, see alignment E=8.1e-17 PF08482: HrpB_C" amino acids 667 to 799 (133 residues), 178.6 bits, see alignment E=1.1e-56

Best Hits

Swiss-Prot: 68% identical to HRPB_ECOLI: ATP-dependent RNA helicase HrpB (hrpB) from Escherichia coli (strain K12)

KEGG orthology group: K03579, ATP-dependent helicase HrpB [EC: 3.6.4.13] (inferred from 70% identity to ddd:Dda3937_00507)

Predicted SEED Role

"ATP-dependent helicase HrpB"

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.13

Use Curated BLAST to search for 3.6.4.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (812 amino acids)

>IAI46_21195 ATP-dependent helicase HrpB (Serratia liquefaciens MT49)
MSSLPVSAVLDELLTALQSAPQVLLHAPTGAGKSTWLPLQILAKAGLPGRIIMLEPRRLA
AKNVAYRLAQQLGEEPGQTVGYRMRAESKSGPETKLLVVTEGILTRMLQQDAELQGVSLV
ILDEFHERSLQADLALALLLDVQQGLRDDLKLLIMSATLDNARLAQLLPQAPAVVSAGRS
FPVERQYQPLASHQRLEDGVAAAVKRLLSEQTGSLLLFLPGVAEINRVLERLNGEVAADT
ELCPLYGALPLAQQQKAIQPAPTGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARYDV
RNGLTRLVTQRVSQASMIQRAGRAGRLEPGICWHLFAKEQAERAAEHAEPEILQSDLAGF
WLELLQWGCHDVGQLTWLDRPPETALAAAKRLLQQLGATDDADKLTARGRQMAVLGCEPR
LAAMLTHGAELGADGLATAAALAALLEEPPRGGQMDIGYWLSRPQPNWQRRATQLARRLQ
VKAGRIDVELAPRLLALAFTDRIAQRRGQDGRYLLANGMGAAMNQDEALSRAPWLIVPSL
LQGHNSPDARILLALPVEIDALAAQLPAMVSQQTAVEWDEEKGTLRAWKRQQIGRLTLRA
QPLAKPADEELQQALINWVRAQGIAVLNWDTAAEQLRLRLQCAQNWLPEAAWPPVDDESL
LASLEKWLLPSLGGVRDMRGLKQVNIAEALARLLNWQQKQRLDNALPTHYTVPTGSRLPI
RYDAGKPPALAVRLQEVFGEQRSPMLAEGRIPVVLELLSPAHRPLQITGDLAAFWQGAYR
EVQKEMKGRYPKHVWPDDPANTAPTRRTKKYQ