Protein Info for IAI46_21140 in Serratia liquefaciens MT49

Annotation: biosynthetic arginine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 32 to 656 (625 residues), 899.7 bits, E=5.2e-275
• PF02784: Orn_Arg_deC_N
  • amino acids 101 to 367 (267 residues), 198.3 bits, E=2.1e-62
• PF17810: Arg_decarb_HB
  • amino acids 392 to 478 (87 residues), 99.6 bits, E=1.5e-32
• PF17944: Arg_decarbox_C
  • amino acids 606 to 655 (50 residues), 58.7 bits, 9.3e-20

Best Hits

Swiss-Prot: 91% identical to SPEA_YERPE: Biosynthetic arginine decarboxylase (speA) from Yersinia pestis

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 90% identity to ddd:Dda3937_00418)

MetaCyc: 87% identical to biosynthetic arginine decarboxylase (Escherichia coli K-12 substr. MG1655)
Arginine decarboxylase. [EC: 4.1.1.19]

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (17/17 steps found)
• superpathway of polyamine biosynthesis I (8/8 steps found)
• superpathway of L-arginine and L-ornithine degradation (11/13 steps found)
• superpathway of putrescine biosynthesis (4/4 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (9/11 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (2/2 steps found)
• putrescine biosynthesis I (2/2 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of polyamine biosynthesis II (6/8 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (2/3 steps found)
• putrescine biosynthesis II (2/3 steps found)
• spermidine biosynthesis III (2/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.19

Protein Sequence (658 amino acids)

>IAI46_21140 biosynthetic arginine decarboxylase (Serratia liquefaciens MT49)
MSDDLLIHRPSATGESISLRSMQEVAMNDRDASKMLRTYNVAYWGNNYYDVNELGHISVC
PDPDVPQARVDLAELVKQRQNDGLRLPALFCFPQILQHRLRSINAAFKRARESFGYEGGY
FLVYPIKVNQHRRVIESLVNSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYI
RLALIGEKLGHKVYLVIEKMSEINMVLEEAERLNVVPRLGVRARLASQGSGKWQSSGGEK
SKFGLAAIQVLKLVETLREAGRLDSLQLLHFHLGSQLANIRDIATGVRESARFYVELHKL
GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNVIWGIGDACNEHGLPHPTVITE
SGRAVTAHHTVLVSNVIGVERNEFSEPLPPAEDAPRALESMWETWQEMNEPENRRSLREW
LHDSQMDLHDVHTQYAHGMLDLTKRAWAEQLYLNICNKIQQQLDPSNRAHRPIIDELQER
MADKFYVNFSLFQSMPDAWGIDQLFPVLPLEGLDKPPEGRAVLLDITCDSDGTIDHYIDG
DGVATTMPMPPYDPENPPALGFFMVGAYQEILGNMHNLFGDTASVDVFVFPDGTVETELS
DEGDTVADMLEYVQLDPTALLAKFRDQVKETDLDSELQAQFLEEFEAGLYGYTYLEDE