Protein Info for IAI46_20990 in Serratia liquefaciens MT49

Annotation: aromatic acid/H+ symport family MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 449 transmembrane" amino acids 21 to 46 (26 residues), see Phobius details amino acids 60 to 79 (20 residues), see Phobius details amino acids 90 to 109 (20 residues), see Phobius details amino acids 115 to 135 (21 residues), see Phobius details amino acids 147 to 168 (22 residues), see Phobius details amino acids 175 to 196 (22 residues), see Phobius details amino acids 258 to 277 (20 residues), see Phobius details amino acids 294 to 313 (20 residues), see Phobius details amino acids 322 to 341 (20 residues), see Phobius details amino acids 347 to 369 (23 residues), see Phobius details amino acids 385 to 407 (23 residues), see Phobius details amino acids 413 to 432 (20 residues), see Phobius details PF07690: MFS_1" amino acids 29 to 334 (306 residues), 127.6 bits, see alignment E=8.4e-41 amino acids 296 to 437 (142 residues), 39.9 bits, see alignment E=3.9e-14 PF00083: Sugar_tr" amino acids 33 to 430 (398 residues), 86.3 bits, see alignment E=3.4e-28 PF06779: MFS_4" amino acids 45 to 212 (168 residues), 36.5 bits, see alignment E=5.7e-13

Best Hits

Swiss-Prot: 44% identical to GALT_PSEPU: Gallate transporter (galT) from Pseudomonas putida

KEGG orthology group: K08195, MFS transporter, AAHS family, 4-hydroxybenzoate transporter (inferred from 90% identity to spe:Spro_3941)

Predicted SEED Role

"4-hydroxybenzoate transporter" in subsystem Cinnamic Acid Degradation or Gentisare degradation or Phenylpropanoid compound degradation or Salicylate and gentisate catabolism or p-Hydroxybenzoate degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (449 amino acids)

>IAI46_20990 aromatic acid/H+ symport family MFS transporter (Serratia liquefaciens MT49)
MSQNTARISEIIDNAKISPYQILILTLCFLIVLLDGFDTAIIGYIAPALREEWQLLPAQL
SPTFGAGLFGLLLGSLIFGPVADAIGRKRVLLASILIFGGGTLASAYTSSIESLTLLRLI
TGIGLGGAMPTCITLSSEYSPARRRMIMVTLSWSGFTAGLALGGILAGQVIPAFGWRGLL
MLGGIAPLLLLPLLAWQMPESARFMSASPKHADSLRQVVERITGKSWAGVTIIDDERPAL
ARSPISHLFIEGRAVRTLLLWVAFFCSLFVFYLLTSWLPSILKDTGYDIVHASRIGAMVP
LGGTLGAILMALLMDRVGPYRVLALSYLGAALVIGATGYLMGDAYTLAVTVFLIGFGVAG
AQNGLNLVSATLYPTAARVTGVSWAMASGRFGSIVGSMLGAWMIVAAGTSEMFFIWLALP
VLVGSAAIFLLYRLSVNRRVPVPDSALSN