Protein Info for IAI46_20780 in Serratia liquefaciens MT49

Annotation: HD domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 202 PF12917: YfbR-like" amino acids 18 to 129 (112 residues), 51.1 bits, see alignment E=2.1e-17 PF13023: HD_3" amino acids 23 to 185 (163 residues), 178.4 bits, see alignment E=1.7e-56 PF01966: HD" amino acids 45 to 104 (60 residues), 24.9 bits, see alignment E=3.2e-09

Best Hits

KEGG orthology group: K07023, putative hydrolases of HD superfamily (inferred from 93% identity to spe:Spro_3901)

Predicted SEED Role

"HMP-PP hydrolase (pyridoxal phosphatase) Cof, detected in genetic screen for thiamin metabolic genes (PMID:15292217)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (202 amino acids)

>IAI46_20780 HD domain-containing protein (Serratia liquefaciens MT49)
MSSAVPALDFGSMTQVIQFLMEIDKLKSVQRRTKVLGTQRQENSAEHSWHFAVGAMSLAP
YAGKDVDIQRVIQMALLHDIVEIDAGDVLVYDLAARAAIHDQEVAAARRLFGMLPDAQRE
YFTALWQEYEDGESADARFALVLDRTMPMLMNLHNEGQSWVENGISLEQVLSRNTMIEEV
YPELWKHLLHHLQDAQRKGWLK