Protein Info for IAI46_20540 in Serratia liquefaciens MT49

Annotation: MBL fold metallo-hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 294 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF00753: Lactamase_B" amino acids 41 to 227 (187 residues), 38.8 bits, see alignment E=5.1e-14

Best Hits

KEGG orthology group: None (inferred from 96% identity to spe:Spro_3840)

Predicted SEED Role

"Metallo-beta-lactamase superfamily protein PA0057" in subsystem PA0057 cluster

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (294 amino acids)

>IAI46_20540 MBL fold metallo-hydrolase (Serratia liquefaciens MT49)
MFKKSLLTLAFAGIATVSTFATAANTLTMEVYNPGEKSVFPVSSEIISGKHEVALIDAQF
QRNDAEALVKKIKATGKKLTTVYISHSDPDFYFGLDVIKAAFPEAKIIASPGTIEEINAT
KDGKVAYWGPILKGNAPKAVVVPQALQGDSFTVDGQKVEVKGLTGPTPERTYVWIPALKA
VVGGVPVAGDNIHPWIADNQTVESRAHWQQTLEGIKALKPEVVVPGHFLPGADQTLKSVT
FTQNYLTTLEAELPKAKDSAALVAAMKKHYPDLKDESSLELSAKVLKGEMKWPQ