Protein Info for IAI46_20300 in Serratia liquefaciens MT49

Annotation: alpha-2-macroglobulin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1800 1900 1993 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 39 to 60 (22 residues), see Phobius details amino acids 72 to 94 (23 residues), see Phobius details PF11974: bMG3" amino acids 615 to 718 (104 residues), 82.6 bits, see alignment 6.9e-27 PF01835: MG2" amino acids 728 to 827 (100 residues), 65.9 bits, see alignment 1.4e-21 PF17972: bMG5" amino acids 838 to 961 (124 residues), 49.1 bits, see alignment 3.1e-16 PF17962: bMG6" amino acids 967 to 1073 (107 residues), 24.7 bits, see alignment 8.9e-09 PF07703: A2M_BRD" amino acids 1093 to 1231 (139 residues), 75.4 bits, see alignment 2.4e-24 PF00207: A2M" amino acids 1299 to 1377 (79 residues), 44 bits, see alignment (E = 6.7e-15) PF17973: bMG10" amino acids 1836 to 1974 (139 residues), 69.7 bits, see alignment 1.1e-22

Best Hits

Swiss-Prot: 71% identical to A2MGH_YERPE: Alpha-2-macroglobulin homolog (YPO2573) from Yersinia pestis

KEGG orthology group: K06894, (no description) (inferred from 80% identity to rah:Rahaq_0245)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1993 amino acids)

>IAI46_20300 alpha-2-macroglobulin (Serratia liquefaciens MT49)
MDLLKFILRLPFTLIKGAFRLLALSLALLGRLFRPLIGNLAWSAPAWWTALSGGVKRAFL
RLESGVNKYPKAISLALLVLLCIAGGAVYGWHWWLNRPQPIEPAPMVYQQTDVQAAGPEA
INYAVQKPTPQKLSLTFSHSAAPLTDVGKAVTKGVTLKPQAEGQWIWNDASTLVFTPKKP
LPMGTQYQVNLDPATLLAPQIKLANTRYTFNVPAFNYQLGQAEYYQDPQDPKKRSAIFNL
KFNAPLDVTSFEKQVSLGLKEGNAKSEKKLNFSLVYDEKKLNAWIHSEPLQALDQGGVVH
LTVGKGIKATVPANAIDEVKSNRVTVPTLYSLALSDASAQVVDAEGAKGQRALIVAFSDA
VKDKELVRATKAWLLPQHDPSDAEAAKDPNDFYQWDTDSVAKNVLAQSMPLTLTLNEAEE
SYQPQFSFKFDAPAHRFMLLEIDNQLVSNGGYKMPKKAYRVIEVPEFPKSLQFMSQGSLL
SVNGDKQISVAARNVAGLRLDIKRVIPSQLQHIVSFKSREYSSAEFNRLDDEYFTEHFKY
QTALNNDQPGVVNYQGIDLSRYLSTNPDSHRGVFLLTLSEWQPNRKPAEEEAGADESEEE
SGDQAGVGDSRFVVVTDLGIVAKSSQDKTRDVFVQSIHSGAPVGSAKVSVIAKNGVTLLS
QITDTNGHVRFPALDVYTNERQPVMFLVEKEGDVSFLPTGSYNDRGLDFSRFDIAGEQTP
TDPRALSSYLFSDRGVYRPGDTFNVGLITRAADWSVGLAGVPVRAEIRDPRDKLMTTVPL
TLGASGFNELSYTTDENSPTGEWNVYLYLVGKNHDTSTLLGHTSVNVKEFEPDQLKVKLE
LTPNRQQGWVKPSELQAKIDVQNLFGTPAQDRRVTSRLTLRPMYPSFDRFPDYAFYENRQ
NSDGFETELEERTTDEQGAANIPLDLKGYADATYQLQLLSEAFVAGGGRSVAATARALVS
PYDYLVGVKADGDLGYINRDALRQLNVIAVDPSLKQIALADLKLVLIEQKYISVLTKQDS
GVYKYQSKMKEVTLSEQPLALSEQGNDLRLATDKPGDFVLVIEDAQGKVLNRVAYSVAGN
ANLSRSLDRNAELKLKLNQAEYQPGEEIEVSINAPYTGSGLITIEKDRVYAWQWFHSDTT
SSVQKIRLPAGMEGNGYINVQFVRDVNSSEIFMSPLSYGVMPFKISTRARQNGLEVTAPS
VIKPGEDLTMTVKTDGPQQVALFAVDEGILQVARYRLKDPLEFFFSKRELSVTSSQILDL
ILPEFSKLMALTAAPGGDAGEGLDLNLNPFKRKRDKPVAYWSGITEVNGEKAFVYPVPDY
FNGKIRVMAISVTPDKIGKAQTAATVRDNFIMTPNVPAMVAPGDEFDVSVGVSNNLEGLN
GQPVAVSVHLTPPPQLDVVGNAVQGLSLAEKREGVVNFRLRAKSALGDAPLVFDASYGDK
SSRRTVSTSVRPAMPYRTQTVMGRMSGGSQNVEGLRQMFDAYAQRQAAVSHSPLVLTNGL
AQYLADYPYYCSEQIVSRSIPLILQSRHPEMAGGLSQTEVSKQLRNLLGVLRSRQNDSGA
IGAWRSSPDADPFVTPYVVQYLLEAKQAGYALPEGMLEEANGALRELAASGFDDLYRLRL
RSWAIYLLTRQGEVTTNALAMVQDTLQKRYPDSWKTDLSTLYLASSYQLLKMDDEAAALL
QPSWQQLSKAYDSAWWTQNYFDPLVQDATRLYLITRHFPEKVASIPPQVLENMVKALKEE
RYTTYSSAMSILALESYSAQVAQSANAGSLDITQIGKGGNAAPQRIAELQGLFAKGQFTA
DAAAVRFTNSGDAPAWYSVTQAGYNLAAPQKALARGLEITRDYTDEQGKPVTQVTLGQKV
NVHLKIRANAKEGLSNLAIVDLLPGGFEVVQQTPPEPAADEDSEAEAPSSGWQSPLAASG
SSWAPDYSDIREDRVIIYGSASTDVQEFVYQIKATNTGSFIIPPAYGEAMYDREVQAMSV
GSGKLVVVPAENK