Protein Info for IAI46_20250 in Serratia liquefaciens MT49

Annotation: UMP kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02075: UMP kinase
  • amino acids 9 to 240 (232 residues), 343.4 bits, E=3.3e-107
• PF00696: AA_kinase
  • amino acids 11 to 219 (209 residues), 117.4 bits, E=4.2e-38

Best Hits

Swiss-Prot: 100% identical to PYRH_SERP5: Uridylate kinase (pyrH) from Serratia proteamaculans (strain 568)

KEGG orthology group: K09903, uridylate kinase [EC: 2.7.4.22] (inferred from 100% identity to spe:Spro_3788)

MetaCyc: 91% identical to UMP kinase (Escherichia coli K-12 substr. MG1655)
Cytidylate kinase. [EC: 2.7.4.14, 2.7.4.22]

Predicted SEED Role

"Uridine monophosphate kinase (EC 2.7.4.22)" (EC 2.7.4.22)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleosides salvage (10/10 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (8/9 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (4/4 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• CMP phosphorylation (2/2 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.4.14

Use Curated BLAST to search for 2.7.4.14 or 2.7.4.22

Protein Sequence (241 amino acids)

>IAI46_20250 UMP kinase (Serratia liquefaciens MT49)
MATNAKPVYQRILLKLSGEALQGAEGFGIDASVLDRMAQEVKELVELGIQVGVVIGGGNL
FRGAGLAQAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDNYSWA
EAISLLRNNRVVIFSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPVKNPD
ATLYEHITYQDVLERELKVMDLAAFTLARDHGLPIRVFNMNKPGALRRVVMGENEGTLIS
K