Protein Info for IAI46_20225 in Serratia liquefaciens MT49

Annotation: sigma E protease regulator RseP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 451 transmembrane" amino acids 6 to 29 (24 residues), see Phobius details amino acids 56 to 73 (18 residues), see Phobius details amino acids 99 to 124 (26 residues), see Phobius details amino acids 377 to 399 (23 residues), see Phobius details amino acids 427 to 446 (20 residues), see Phobius details TIGR00054: RIP metalloprotease RseP" amino acids 3 to 451 (449 residues), 519.6 bits, see alignment E=3e-160 PF02163: Peptidase_M50" amino acids 10 to 439 (430 residues), 259.6 bits, see alignment E=4e-81 PF00595: PDZ" amino acids 223 to 259 (37 residues), 29 bits, see alignment 2.3e-10 PF13180: PDZ_2" amino acids 223 to 287 (65 residues), 35.2 bits, see alignment E=2.5e-12 PF17820: PDZ_6" amino acids 227 to 278 (52 residues), 39 bits, see alignment 1.2e-13

Best Hits

Swiss-Prot: 86% identical to RSEP_YERPE: Protease RseP (rseP) from Yersinia pestis

KEGG orthology group: K11749, regulator of sigma E protease [EC: 3.4.24.-] (inferred from 98% identity to spe:Spro_3783)

MetaCyc: 76% identical to intramembrane zinc metalloprotease RseP (Escherichia coli K-12 substr. MG1655)
3.4.21.-; RXN-18678

Predicted SEED Role

"Membrane-associated zinc metalloprotease" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (451 amino acids)

>IAI46_20225 sigma E protease regulator RseP (Serratia liquefaciens MT49)
MGSVLWNLVAFLIALGVLITVHEFGHFWVARRCGVRVERFSIGFGRALWRRTDRQGTEYV
IALIPLGGYVKMLDERVDSVAPEFRHQAFNNKTVWQRAAIVSAGPIANFLFAILAYWLVF
IIGVPSFRPVIGEISPQSIAAHAEISPGMELKSVDGIETPDWESVRLALVAKIGDAETEV
GIAPFGSSQVVTKTLDLRQWNFEPDKQDPVVALGIIPRGPQIESVLAEVQSGSAAQKAGL
QAGDRIVKVDGQLLGRWQTLVKRIHNGPGQPLVLEIERNGAPLSLTLIPDTKPVGKDKSV
GFAGIIPKVLPLPDEYKTIRQYGPFPALYQAGDKTWQLMSLTVKMLGKLITGDVKLNNLS
GPISIAQGAGASAGVGLVYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKLKGGPV
SERVQDYSYRIGSIVLVLLMGLALFNDFSRL