Protein Info for IAI46_20085 in Serratia liquefaciens MT49

Annotation: MetQ/NlpA family lipoprotein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 271 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details TIGR00363: lipoprotein, YaeC family" amino acids 14 to 271 (258 residues), 486.3 bits, see alignment E=1.2e-150 PF04069: OpuAC" amino acids 32 to 206 (175 residues), 26.8 bits, see alignment E=4e-10 PF03180: Lipoprotein_9" amino acids 33 to 271 (239 residues), 328.3 bits, see alignment E=2.1e-102

Best Hits

Swiss-Prot: 91% identical to METQ_SALTY: D-methionine-binding lipoprotein MetQ (metQ) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02073, D-methionine transport system substrate-binding protein (inferred from 98% identity to srs:SerAS12_3950)

MetaCyc: 90% identical to L-methionine/D-methionine ABC transporter membrane anchored binding protein (Escherichia coli K-12 substr. MG1655)
RXN0-4522 [EC: 7.4.2.11]; 7.4.2.11 [EC: 7.4.2.11]; TRANS-RXN-383 [EC: 7.4.2.11]; TRANS-RXN0-510 [EC: 7.4.2.11]; TRANS-RXN0-511 [EC: 7.4.2.11]

Predicted SEED Role

"Methionine ABC transporter substrate-binding protein" in subsystem Methionine Biosynthesis or Methionine Degradation or Staphylococcal pathogenicity islands SaPI

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (271 amino acids)

>IAI46_20085 MetQ/NlpA family lipoprotein (Serratia liquefaciens MT49)
MSLKFKSIAAIGALIGTLALAGCGQEEKDPNHIKIGVIVGAEQQVAEIAQKVAKEKYGLD
VELVTFNDYVLPNEALSKGDIDLNAFQHKPYLDQQIKDRGYKLVPVGNTFVYPIAGYSKK
IKSLDELKDGSQVALPNDPTNLGRSLLLLQKVNLIKLKDGVGLLPTVLDVTENPKNLKLV
ELEAPQLPRSLDDQQIALAVINTTYASQIGLTPAKDGLFVEDKDSPYVNLLVAREDNKDA
ENVKKFVQAYQSDEVNEAANKIFNGGAVKGW