Protein Info for IAI46_19480 in Serratia liquefaciens MT49

Annotation: membrane-bound lytic murein transglycosylase MltF

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF00497: SBP_bac_3" amino acids 46 to 267 (222 residues), 103.9 bits, see alignment E=9.6e-34 PF01464: SLT" amino acids 296 to 402 (107 residues), 89.5 bits, see alignment E=1.2e-29

Best Hits

Swiss-Prot: 99% identical to MLTF_SERP5: Membrane-bound lytic murein transglycosylase F (mltF) from Serratia proteamaculans (strain 568)

KEGG orthology group: None (inferred from 98% identity to spe:Spro_3655)

MetaCyc: 62% identical to membrane-bound lytic murein transglycosylase F (Escherichia coli K-12 substr. MG1655)
4.2.2.f [EC: 4.2.2.f]

Predicted SEED Role

"Transglycosylase, Slt family"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.2.f

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (486 amino acids)

>IAI46_19480 membrane-bound lytic murein transglycosylase MltF (Serratia liquefaciens MT49)
MKRLKINYILIGVVTLLLALALWPNITWRGGQGGQLEEIKSRGELRISTLNSPLTYFTTK
QGPSGLDYELAKRFANYLGVKLVVIPHKNINDLFDDLDDDDADLLAAGLIYNQDRLSRAR
TGPAYYSVSQQLVYRLGTARPKSFADIKGKLAVASGSAHVSTLKQLKQSKFPDLSWEASS
DLTSKELLEQVADGKLDYTLGDSVTIALLQRIHPQLAVAFDVTDEEPVTWYLKRGTDDSL
YAAMLDFYSQMVDDGTLARLEEKYLGHVGSFDYVDTKTFLSAIDSVLPTFRSLFEKYASE
IDWKLLAAIAYQESHWNPQATSPTGVRGLMMLTRATADGLGVNDRLDPEESIQGGALYLQ
RLMAKVPDTVPEDERIWFALAAYNMGWGHMLDARKLTKMQKGNPDSWVDVKQRLPMLSQK
RYYPQLTYGYARGREAYNYVENIRRYQVSLVGYLQERERKAAQEAAEQAELGKGYPAVAP
ELALNF