Protein Info for IAI46_19440 in Serratia liquefaciens MT49

Annotation: gamma-aminobutyraldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 24 to 479 (456 residues), 527.6 bits, E=1.2e-162

Best Hits

Swiss-Prot: 63% identical to ABDH_SHISS: Gamma-aminobutyraldehyde dehydrogenase (prr) from Shigella sonnei (strain Ss046)

KEGG orthology group: K00130, betaine-aldehyde dehydrogenase [EC: 1.2.1.8] (inferred from 97% identity to spe:Spro_3647)

MetaCyc: 63% identical to gamma-aminobutyraldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]; 1.2.1.19 [EC: 1.2.1.19]

Predicted SEED Role

"4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19)" in subsystem Polyamine Metabolism (EC 1.2.1.19)

MetaCyc Pathways

• superpathway of L-arginine and L-ornithine degradation (11/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (9/11 steps found)
• choline degradation I (2/2 steps found)
• glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
• glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
• superpathway of ornithine degradation (6/8 steps found)
• choline-O-sulfate degradation (2/3 steps found)
• glycine betaine biosynthesis III (plants) (2/3 steps found)
• putrescine degradation IV (2/3 steps found)
• L-lysine degradation X (4/6 steps found)
• β-alanine biosynthesis I (1/2 steps found)
• β-alanine biosynthesis IV (1/2 steps found)
• putrescine degradation I (1/2 steps found)
• putrescine degradation V (1/2 steps found)
• choline degradation IV (2/4 steps found)
• L-lysine degradation I (4/7 steps found)
• dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
• dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)
• superpathway of L-lysine degradation (13/43 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glycine, serine and threonine metabolism
• Urea cycle and metabolism of amino groups
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.19, 1.2.1.8

Use Curated BLAST to search for 1.2.1.19 or 1.2.1.8

Protein Sequence (487 amino acids)

>IAI46_19440 gamma-aminobutyraldehyde dehydrogenase (Serratia liquefaciens MT49)
MADVHLLSGLSCQQFINGQSVEGEGQQECIVNPANGETLVSITEASSVQVGNAVKAAQQA
FASWSRTTPAYRAAILLRIADAIERQAERLAGLEALNCGKPLHQALNDDLPAAIDVFRFF
AGAVRTQQGQLAGEYIEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKIAPALAAGNTVVF
KPSEHTPLTILALVPALQEILPSGVLNIVYGGGEGVGSHLVGHPQVRLVSVTGDIVTGQK
ILQAAAKSVKRTHLELGGKAPVIVCDDADLDEVVNSIRTYGYYNAGQDCTAACRIYAQAG
IYPKLVDALGEAVASLRFARKRDEDNEIGPLISSRQRDRVASFVERALSQPHIELITGAA
AHSGPGFYYQPTLLAGCLQSDEIVQREVFGPVVSITRFEHLEQAVNWANDSEYGLASSVW
TQNIDRALHIAAHLQYGSTWINTHFTLASEMPHGGLKRSGYGKDLSSDSLQDYSVVRHVM
AKFKASF