Protein Info for IAI46_19300 in Serratia liquefaciens MT49

Annotation: LacI family DNA-binding transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 PF00356: LacI" amino acids 3 to 48 (46 residues), 73.8 bits, see alignment 1.5e-24 PF00532: Peripla_BP_1" amino acids 62 to 306 (245 residues), 80.9 bits, see alignment E=2.4e-26 PF13407: Peripla_BP_4" amino acids 63 to 275 (213 residues), 37.7 bits, see alignment E=3.5e-13 PF13377: Peripla_BP_3" amino acids 169 to 329 (161 residues), 118 bits, see alignment E=9.4e-38

Best Hits

Swiss-Prot: 38% identical to GALS_ECOLI: HTH-type transcriptional regulator GalS (galS) from Escherichia coli (strain K12)

KEGG orthology group: K02529, LacI family transcriptional regulator (inferred from 90% identity to spe:Spro_3616)

Predicted SEED Role

"Putative transcriptional regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (350 amino acids)

>IAI46_19300 LacI family DNA-binding transcriptional regulator (Serratia liquefaciens MT49)
MATMKDVARRAGVSTATVSRVINSTAYVEPVTRERVEKAMREFNYHRNAAALALAKRSGN
MLGLLTGNLDDPFFSRLARGVEDITRKDGVKLMVCSGGHQAELEKNGLDFLINQGCESIV
AHVTRMSDADILRYAAHTPAMVVINRYLPAIANRCIWLDNVSASQAATRMLIERGHRNIA
CITTDLPIDDRKQRLEGYRTAMAEAGIAVPGDWIISVPFNEQGGEAAAEKILASKQAFTA
ALTFNDVMAAGMMRTFRQRRMNLPEDISIVGFDDVALAKYLHPPLTTVHYPIEKMARRAA
NLALQLNSGTAVTPQNNRFSAELILRDSVAFVEKNPHLKKTRLPSESSLT