Protein Info for IAI46_18940 in Serratia liquefaciens MT49

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1113 transmembrane" amino acids 17 to 38 (22 residues), see Phobius details amino acids 44 to 60 (17 residues), see Phobius details amino acids 68 to 90 (23 residues), see Phobius details amino acids 96 to 113 (18 residues), see Phobius details amino acids 125 to 148 (24 residues), see Phobius details amino acids 159 to 180 (22 residues), see Phobius details amino acids 188 to 206 (19 residues), see Phobius details amino acids 212 to 229 (18 residues), see Phobius details amino acids 235 to 256 (22 residues), see Phobius details amino acids 268 to 289 (22 residues), see Phobius details amino acids 388 to 406 (19 residues), see Phobius details PF05231: MASE1" amino acids 21 to 270 (250 residues), 58.4 bits, see alignment E=2.8e-19 TIGR00229: PAS domain S-box protein" amino acids 298 to 422 (125 residues), 88.9 bits, see alignment E=2.9e-29 amino acids 552 to 681 (130 residues), 39.3 bits, see alignment E=6.5e-14 PF00989: PAS" amino acids 302 to 413 (112 residues), 36.7 bits, see alignment E=1.5e-12 amino acids 561 to 671 (111 residues), 37.1 bits, see alignment E=1.1e-12 PF13426: PAS_9" amino acids 313 to 415 (103 residues), 39.8 bits, see alignment E=1.8e-13 amino acids 567 to 673 (107 residues), 25.8 bits, see alignment E=4.2e-09 PF08448: PAS_4" amino acids 313 to 418 (106 residues), 23.6 bits, see alignment E=2.1e-08 amino acids 561 to 675 (115 residues), 46.5 bits, see alignment E=1.6e-15 PF08447: PAS_3" amino acids 325 to 407 (83 residues), 44.8 bits, see alignment 4.9e-15 amino acids 451 to 537 (87 residues), 56.3 bits, see alignment 1.3e-18 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 683 to 845 (163 residues), 131.8 bits, see alignment E=2e-42 PF00990: GGDEF" amino acids 685 to 841 (157 residues), 139.8 bits, see alignment E=2.8e-44 PF00563: EAL" amino acids 894 to 1096 (203 residues), 91.8 bits, see alignment E=1.9e-29

Best Hits

KEGG orthology group: None (inferred from 85% identity to srs:SerAS12_3752)

Predicted SEED Role

"Sensory box/GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1113 amino acids)

>IAI46_18940 diguanylate cyclase (Serratia liquefaciens MT49)
MDISAPNHLITRQGALLTHSLLAAVAVFLLALLCLTLSNESSHFTPLWFPTAAIIAVLFR
HSPRQWGLPLLACGVGIVAASVTLFGFSWFPVKLTLINLLEAVVCTLLLRRMLLQDDPLN
SLASWLKFVVCAVIFTPLFSALLAAWWVPAPGHPFWHPFSTWFISEAIGVLSLTPIGLVY
RRRMLDTLNLYTLLLTLIVALTFSYLALSYLPFPFTFVILPLLWAAIALPRLEAFVICFC
TTLMITVMISIGLLHFHAPTGPFSDIEIYLPILLILIPAHSMTMVMHAFRVEKQHIVESE
TRFRNALEYSAIGMALVSPQGKWLQVNQALCKLLDYTPEALRRLTFQEITHPDDLNADLT
QLHDLLDGHISSYTLEKRYIRSDGEHVWALLAVSLVRDAEGLPLYFISQVEDISELKRTA
AENHRLMERITLANKVGGIGVWEWMMHGEELTWDKRMFELYDLSPDQTPTFSLWRTLLVP
EDRERTDREMATLLKRPGPFVLEFRLLTREGKVRHIRGQGNVILDAQGLPLRMIGTNIDM
TEVRNLTEALHEEKERLYITLDAIGEAVISTDDEMHITFMNPVAEQMCGWPLSLAIGMPV
AGVVRMTNGKDGEEVENPIQCCLQENRQLSADYALVLHGRDGRCFDIQQSVSPLKTIDGN
VMGAVMVLQDVTASRELMQKLSYSASHDALTTLPNRTSFEKRLKAAIANATEKRLQHALV
FLDLDRFKAVNDNAGHAAGDALLKDLSLLMRHHLRNSDCLARLGGDEFGLILFDCTREQA
QSLIQQLVNHISQHPFFWEGKIYHVGASAGVTRIDADAGKSSELLAQADIACYTAKHRGR
GQVYLYEARQKMILERQHELLTRQEVTDIINDGQLLLHVRAVAPPKTPLAVCFYQLKLQV
RDQDGQALASDDFISAARLYDLTKEVDRWIIGQILTQRAPDIARKGLSIALPLTTDSLLD
ASFQDELLTALDASPLQPGALLLAVDDAVVLEHAGICRPFLQQLQQRGCKLIVNGFGHSL
NAFDELHGQKIDYIRVDERFITNVHCNQMDELMVSMLNGATHRVHAQTLAGPAHQQITLN
TLQAIGIDLSDGDAIALEQSLTELLSGGYFGIR