Protein Info for IAI46_18885 in Serratia liquefaciens MT49

Annotation: phosphoribosylformylglycinamidine cyclo-ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00878: phosphoribosylformylglycinamidine cyclo-ligase
  • amino acids 7 to 335 (329 residues), 506.1 bits, E=2.3e-156
• PF00586: AIRS
  • amino acids 60 to 164 (105 residues), 87.8 bits, E=6.8e-29
• PF02769: AIRS_C
  • amino acids 176 to 339 (164 residues), 140.9 bits, E=3.9e-45

Best Hits

Swiss-Prot: 88% identical to PUR5_PECCP: Phosphoribosylformylglycinamidine cyclo-ligase (purM) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K01933, phosphoribosylformylglycinamidine cyclo-ligase [EC: 6.3.3.1] (inferred from 98% identity to spe:Spro_3524)

MetaCyc: 87% identical to phosphoribosylformylglycinamide cyclo-ligase (Escherichia coli K-12 substr. MG1655)
Phosphoribosylformylglycinamidine cyclo-ligase. [EC: 6.3.3.1]

Predicted SEED Role

"Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)" in subsystem De Novo Purine Biosynthesis (EC 6.3.3.1)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (26/26 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of 5-aminoimidazole ribonucleotide biosynthesis (6/6 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis II (5/5 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.3.1

Protein Sequence (346 amino acids)

>IAI46_18885 phosphoribosylformylglycinamidine cyclo-ligase (Serratia liquefaciens MT49)
MTDKTSLSYKDAGVDIDAGNALVDRIKGVVKQTRRPEVMGGLGGFGALCALPQKYREPIL
VSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDVDTAA
SVITGIAEGCKQSGCALVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVQSGDA
LIALGASGPHSNGYSLVRKILEVSNTDPTTTLLSGKPLADHLLAPTKIYVKSVLELIEKI
DVHAIAHLTGGGFWENIPRVLPEGMQAVIEESSWQWPAVFNWLQQNGNVSRHEMYRTFNC
GVGMVIALPEEAVESAIALLTAAGEKAWKIGKLTASSDEQQVVING