Protein Info for IAI46_18875 in Serratia liquefaciens MT49

Annotation: uracil permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 429 transmembrane" amino acids 20 to 38 (19 residues), see Phobius details amino acids 44 to 60 (17 residues), see Phobius details amino acids 67 to 83 (17 residues), see Phobius details amino acids 89 to 108 (20 residues), see Phobius details amino acids 119 to 141 (23 residues), see Phobius details amino acids 157 to 176 (20 residues), see Phobius details amino acids 182 to 202 (21 residues), see Phobius details amino acids 225 to 249 (25 residues), see Phobius details amino acids 302 to 326 (25 residues), see Phobius details amino acids 332 to 354 (23 residues), see Phobius details amino acids 366 to 386 (21 residues), see Phobius details amino acids 391 to 412 (22 residues), see Phobius details TIGR00801: uracil-xanthine permease" amino acids 11 to 404 (394 residues), 429.1 bits, see alignment E=9.5e-133 PF00860: Xan_ur_permease" amino acids 16 to 383 (368 residues), 362.4 bits, see alignment E=1.3e-112

Best Hits

Swiss-Prot: 88% identical to URAA_ECO57: Uracil permease (uraA) from Escherichia coli O157:H7

KEGG orthology group: K02824, uracil permease (inferred from 98% identity to spe:Spro_3522)

MetaCyc: 88% identical to uracil:H+ symporter UraA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-132

Predicted SEED Role

"Uracil permease" in subsystem De Novo Pyrimidine Synthesis or Pyrimidine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (429 amino acids)

>IAI46_18875 uracil permease (Serratia liquefaciens MT49)
MTRRVIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGVGTLLYLFI
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVALLVKKAGTGWLDVIF
PPAAMGAIVAVIGLELAGVAANMAGLLPADGVSADTTTITISLVTLGVTILGSVLFRGFL
AIIPILIGVLVGYALSFFMGVVDLTPIREAHWFALPTFYTPRFEWFAIFTILPAALVVIA
EHVGHLVVTANIVKKDLLRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKV
YSTWVIGGAAVLAILLSCVGKLAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDY
NKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIGLSLLFKVISLYRKEEEVTE
APDESAEQK