Protein Info for IAI46_18795 in Serratia liquefaciens MT49

Annotation: AI-2E family transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 356 transmembrane" amino acids 20 to 52 (33 residues), see Phobius details amino acids 72 to 93 (22 residues), see Phobius details amino acids 151 to 177 (27 residues), see Phobius details amino acids 217 to 234 (18 residues), see Phobius details amino acids 240 to 269 (30 residues), see Phobius details amino acids 278 to 301 (24 residues), see Phobius details amino acids 308 to 334 (27 residues), see Phobius details PF01594: AI-2E_transport" amino acids 20 to 345 (326 residues), 263.2 bits, see alignment E=1.7e-82

Best Hits

Swiss-Prot: 77% identical to PERM_ECOLI: Putative permease PerM (perM) from Escherichia coli (strain K12)

KEGG orthology group: K03548, putative permease (inferred from 98% identity to srs:SerAS12_3706)

Predicted SEED Role

"Putative permease PerM (= YfgO)" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (356 amino acids)

>IAI46_18795 AI-2E family transporter (Serratia liquefaciens MT49)
MLEMLLQWYRRRFTDPQAIALLVILLAGFLILYFLHGILTPLLVAIVLAYLLEWPTARLQ
RIGCSRNWAASMVMILFAGIAMLLVFVVAPTAWQQGINLMTDLPGMLNQFYNFAATLPKR
YPALVDAGIIDMMAENLRGRLSGMGESVVKFSLASLVGLLTLAIYLILVPMMMFFLLKDK
EQMLNAVRRVLPRNRGLAGQVWIEMNQQITNYIRGKVLEMVIVGVATYLVFAVLDMRYSL
LLAVLVGFSVLIPYIGAVLVTIPVVVVAMFQWGVGADFWTLIVAYLVVQGLDGNLLVPIL
FSEAVNLHPLVIILSVIIFGGLWGFWGVFFAIPLATLVKAVIHAWPDELRVETEQE