Protein Info for IAI46_18260 in Serratia liquefaciens MT49

Annotation: NupC/NupG family nucleoside CNT transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 395 transmembrane" amino acids 6 to 22 (17 residues), see Phobius details amino acids 30 to 48 (19 residues), see Phobius details amino acids 87 to 111 (25 residues), see Phobius details amino acids 167 to 187 (21 residues), see Phobius details amino acids 193 to 212 (20 residues), see Phobius details amino acids 241 to 265 (25 residues), see Phobius details amino acids 270 to 292 (23 residues), see Phobius details amino acids 334 to 356 (23 residues), see Phobius details amino acids 375 to 394 (20 residues), see Phobius details PF01773: Nucleos_tra2_N" amino acids 10 to 82 (73 residues), 64.5 bits, see alignment E=1.6e-21 PF07670: Gate" amino acids 91 to 191 (101 residues), 59.5 bits, see alignment E=6e-20 PF07662: Nucleos_tra2_C" amino acids 194 to 391 (198 residues), 206.7 bits, see alignment E=5.2e-65

Best Hits

Swiss-Prot: 81% identical to NUPC_ECOL6: Nucleoside permease NupC (nupC) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K11535, nucleoside transport protein (inferred from 99% identity to spe:Spro_3416)

MetaCyc: 81% identical to nucleoside:H+ symporter NupC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-108A; TRANS-RXN-108B; TRANS-RXN-108C; TRANS-RXN-108D; TRANS-RXN-108E; TRANS-RXN-108F; TRANS-RXN-108G; TRANS-RXN-108H; TRANS-RXN-108I; TRANS-RXN-476

Predicted SEED Role

"Na+ dependent nucleoside transporter NupC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (395 amino acids)

>IAI46_18260 NupC/NupG family nucleoside CNT transporter (Serratia liquefaciens MT49)
MSHIAHFALALVVVAILALLVCRDRKSIRIRYVIQLLVIEVLLAYFFLHSEAGLGFVKGF
AALFDKLLGFAGQGTDFVFGGMGDKGLAFFFLKVLCPIVFISALIGILQYIKVLPFIIRI
IGTVLSKVNGMGKLESFNAVSSLILGQSENFIAYKDILGKMSEKRMYTMAATAMSTVSMS
IVGAYMTMLDAKFVVAALVLNMFSTFIVLSLVNPYDTSKEEELHLGNLHEGQSFFEMLGE
YILAGFKVAIIVAAMLIGFIALIAALNGLFSAIFGLSFQEILGYFFYPFAWIMGIPKHEA
LQVGSIMATKLVSNEFVAMMELQKVSAELSPRSLGILSVFLVSFANFSSIGIVAGAIKGL
NEHQGNVVSRFGLKLVYGSTLVSILSASIAGLVLG