Protein Info for IAI46_18240 in Serratia liquefaciens MT49

Annotation: indolepyruvate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02776: TPP_enzyme_N
  • amino acids 6 to 109 (104 residues), 96.7 bits, E=1.3e-31
• PF00205: TPP_enzyme_M
  • amino acids 199 to 324 (126 residues), 66.7 bits, E=2.7e-22
• PF02775: TPP_enzyme_C
  • amino acids 394 to 528 (135 residues), 79.3 bits, E=4.1e-26

Best Hits

KEGG orthology group: None (inferred from 90% identity to srr:SerAS9_3605)

MetaCyc: 60% identical to indolepyruvate decarboxylase subunit (Pantoea agglomerans)
Indolepyruvate decarboxylase. [EC: 4.1.1.74]

Predicted SEED Role

"Pyruvate decarboxylase (EC 4.1.1.1); Alpha-keto-acid decarboxylase (EC 4.1.1.-)" (EC 4.1.1.-, EC 4.1.1.1)

MetaCyc Pathways

• superpathway of anaerobic sucrose degradation (17/19 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (9/9 steps found)
• pyruvate fermentation to acetate VIII (2/2 steps found)
• pyruvate fermentation to ethanol II (2/2 steps found)
• acetaldehyde biosynthesis II (1/1 steps found)
• L-methionine degradation III (2/3 steps found)
• indole-3-acetate biosynthesis VI (bacteria) (2/3 steps found)
• pyruvate fermentation to acetoin (2/3 steps found)
• L-tryptophan degradation VIII (to tryptophol) (2/4 steps found)
• long chain fatty acid ester synthesis (engineered) (2/4 steps found)
• butanol and isobutanol biosynthesis (engineered) (4/8 steps found)

KEGG Metabolic Maps

• 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
• 1- and 2-Methylnaphthalene degradation
• 3-Chloroacrylic acid degradation
• Ascorbate and aldarate metabolism
• Benzoate degradation via hydroxylation
• Biphenyl degradation
• Fluorene degradation
• Glycolysis / Gluconeogenesis
• Phenylalanine metabolism
• Phenylpropanoid biosynthesis
• Purine metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Tyrosine metabolism
• Ubiquinone and menaquinone biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.-, 4.1.1.1, 4.1.1.74

Use Curated BLAST to search for 4.1.1.- or 4.1.1.1 or 4.1.1.74

Protein Sequence (553 amino acids)

>IAI46_18240 indolepyruvate decarboxylase (Serratia liquefaciens MT49)
MNKNYTVADYLLDRLAQIGIRHFFGVPGDYNLQFLDHVIDHPQITWVGCANELNAAYAAD
GYARCKPAAALLTTFGVGELSAVNGIAGSYAEYLPVIHVVGAPALRAQRAGELLHHSLGD
GDFGHFARMAKEVTVAQASLTADNAEGEIDRLLTTALFERRPVYLLLPSDVAEAPLVSKP
APLMLRQANLSPASLQAFIAAARELLLPARRVSLLADFLAERFGAEKVLEQWMNEVDMPH
STLLLGKSVLDETHACFTGTYVGVASEPQVKQLIENADVIINVGVRFTDTITAGFSQHLP
ADKCIDLQPFEARVGQQVFSQIPMRDAVIALHQLTLSLANQWQRSEIKRSALPDPNGSGL
DQHGFWQQIQGFLRPGDILLAEQGSACFGAASLSLPQGCRFIVQSLWGSIGYTLPAAFGA
QTAEPERRVVLLIGDGSAQLTVQELGSMLRDGLKPVIFLLNNDGYTIERAIHGPNQRYND
IAHWNWTQLPQALGAERQVKALRVSEPEQLRQVLSEVADSPQLAFVEVVLPKMDIPELLQ
TISSALQSRNAAA