Protein Info for IAI46_17555 in Serratia liquefaciens MT49

Annotation: 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03695: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
  • amino acids 14 to 251 (238 residues), 266.3 bits, E=1.3e-83
• PF00561: Abhydrolase_1
  • amino acids 15 to 239 (225 residues), 59 bits, E=8.6e-20
• PF12697: Abhydrolase_6
  • amino acids 17 to 246 (230 residues), 69.3 bits, E=1.2e-22

Best Hits

Swiss-Prot: 90% identical to MENH_SERP5: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH) from Serratia proteamaculans (strain 568)

KEGG orthology group: K08680, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase [EC: 4.2.99.20] (inferred from 90% identity to spe:Spro_3282)

MetaCyc: 44% identical to 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (Escherichia coli K-12 substr. MG1655)
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. [EC: 4.2.99.20]

Predicted SEED Role

"2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC 4.2.99.20)" in subsystem Menaquinone and Phylloquinone Biosynthesis (EC 4.2.99.20)

MetaCyc Pathways

• superpathway of chorismate metabolism (54/59 steps found)
• superpathway of menaquinol-8 biosynthesis I (10/10 steps found)
• superpathway of demethylmenaquinol-8 biosynthesis I (9/9 steps found)
• 2-carboxy-1,4-naphthoquinol biosynthesis (7/7 steps found)
• superpathway of menaquinol-10 biosynthesis (9/10 steps found)
• superpathway of menaquinol-11 biosynthesis (9/10 steps found)
• superpathway of menaquinol-12 biosynthesis (9/10 steps found)
• superpathway of menaquinol-13 biosynthesis (9/10 steps found)
• superpathway of menaquinol-6 biosynthesis (9/10 steps found)
• superpathway of menaquinol-7 biosynthesis (9/10 steps found)
• superpathway of menaquinol-9 biosynthesis (9/10 steps found)
• superpathway of demethylmenaquinol-6 biosynthesis I (8/9 steps found)
• superpathway of demethylmenaquinol-9 biosynthesis (8/9 steps found)
• superpathway of phylloquinol biosynthesis (7/15 steps found)

KEGG Metabolic Maps

• Ubiquinone and menaquinone biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.99.20

Protein Sequence (255 amino acids)

>IAI46_17555 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase (Serratia liquefaciens MT49)
MLATKVLQQGEADRPWLIWLHGLLGNNNEWRVIASRCPEWPSLAIDLPGHGDSVAVTCSS
FDDISAQISSTLQMHGIERYWLVGYSLGGRIAMYHACCGDTTGLQGVIIEGGNPGLADPA
LRAQRLTHDAAWAERFRHEPIEQVLADWYQQPVFANLSAVHRDALIGARKDNSGAAVADM
LEATSLGKQPCLVPQLQQLAIPLVVLCGADDHKFQQLARDAGLPLRIVPQAGHNSHLANP
QDFVAELRTFLVNPG