Protein Info for IAI46_17490 in Serratia liquefaciens MT49

Annotation: SDR family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 11 to 198 (188 residues), 171.6 bits, E=2.9e-54
• PF08659: KR
  • amino acids 12 to 169 (158 residues), 50.7 bits, E=4.2e-17
• PF13561: adh_short_C2
  • amino acids 17 to 248 (232 residues), 200.5 bits, E=6.6e-63
• PF08643: DUF1776
  • amino acids 98 to 190 (93 residues), 28.9 bits, E=1.6e-10

Best Hits

Swiss-Prot: 34% identical to FABG_VIBCH: 3-oxoacyl-[acyl-carrier-protein] reductase FabG (fabG) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K00046, gluconate 5-dehydrogenase [EC: 1.1.1.69] (inferred from 80% identity to ect:ECIAI39_0671)

MetaCyc: 34% identical to 3-oxoacyl-[acyl-carrier-protein] reductase FabG (Escherichia coli K-12 substr. MG1655)
3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]; 1.1.1.100 [EC: 1.1.1.100]; 1.1.1.100 [EC: 1.1.1.100]; 1.1.1.100 [EC: 1.1.1.100]; 1.1.1.100 [EC: 1.1.1.100]; 1.1.1.100 [EC: 1.1.1.100]; 1.1.1.100 [EC: 1.1.1.100]; 1.1.1.100 [EC: 1.1.1.100]

Predicted SEED Role

"3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 1.1.1.100)

MetaCyc Pathways

• ketogluconate metabolism (8/8 steps found)
• biotin biosynthesis I (13/15 steps found)
• superpathway of fatty acids biosynthesis (E. coli) (40/53 steps found)
• superpathway of unsaturated fatty acids biosynthesis (E. coli) (16/20 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (13/16 steps found)
• 8-amino-7-oxononanoate biosynthesis I (9/11 steps found)
• L-idonate degradation (3/3 steps found)
• (5Z)-dodecenoate biosynthesis I (5/6 steps found)
• palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (7/9 steps found)
• cis-vaccenate biosynthesis (4/5 steps found)
• octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (9/12 steps found)
• palmitate biosynthesis III (21/29 steps found)
• gondoate biosynthesis (anaerobic) (3/4 steps found)
• oleate biosynthesis IV (anaerobic) (10/14 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (22/31 steps found)
• (5Z)-dodecenoate biosynthesis II (4/6 steps found)
• stearate biosynthesis II (bacteria and plants) (4/6 steps found)
• stearate biosynthesis IV (4/6 steps found)
• 8-amino-7-oxononanoate biosynthesis IV (3/5 steps found)
• fatty acid elongation -- saturated (3/5 steps found)
• superpathway of fatty acid biosynthesis II (plant) (30/43 steps found)
• tetradecanoate biosynthesis (mitochondria) (17/25 steps found)
• petroselinate biosynthesis (2/6 steps found)
• 2-allylmalonyl-CoA biosynthesis (2/8 steps found)
• anteiso-branched-chain fatty acid biosynthesis (18/34 steps found)
• even iso-branched-chain fatty acid biosynthesis (18/34 steps found)
• odd iso-branched-chain fatty acid biosynthesis (18/34 steps found)
• streptorubin B biosynthesis (15/34 steps found)
• mycolate biosynthesis (16/205 steps found)
• superpathway of mycolate biosynthesis (17/239 steps found)

KEGG Metabolic Maps

• Biosynthesis of unsaturated fatty acids
• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.100, 1.1.1.69

Use Curated BLAST to search for 1.1.1.100 or 1.1.1.69

Protein Sequence (253 amino acids)

>IAI46_17490 SDR family oxidoreductase (Serratia liquefaciens MT49)
MLKNAFSLEGKTALITGAASGLGYAMAECMVASGAKVIIADLNGPLAQQAAENLGPMATY
SQFNVSETTKTQAWVNGLLDQVGQIDILVNNAGNHCKKPIEEMSVEDFESVLDVHVVAAF
ALTKALVPHMKRHGNASVLFTASMTSFLGQPYVAGYAAAKSAYLGLIRALTTELAGAGIR
VNGIAPGWIDTPMLRKAIEGDDERRNKILGRTPMKKFGKPEDIGWAATYLASEAAAFISG
QVLVVDGGALIGF