Protein Info for IAI46_17455 in Serratia liquefaciens MT49

Annotation: two-component system sensor histidine kinase RcsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 956 transmembrane" amino acids 16 to 41 (26 residues), see Phobius details amino acids 317 to 339 (23 residues), see Phobius details PF00512: HisKA" amino acids 472 to 536 (65 residues), 64.2 bits, see alignment 1.9e-21 PF02518: HATPase_c" amino acids 583 to 692 (110 residues), 102.9 bits, see alignment E=2.8e-33 PF09456: RcsC" amino acids 711 to 801 (91 residues), 91.8 bits, see alignment E=4e-30 PF00072: Response_reg" amino acids 831 to 939 (109 residues), 102.3 bits, see alignment E=3.6e-33

Best Hits

KEGG orthology group: K07677, two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC: 2.7.13.3] (inferred from 65% identity to ebi:EbC_30390)

Predicted SEED Role

"Two-component sensor protein RcsC (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (956 amino acids)

>IAI46_17455 two-component system sensor histidine kinase RcsC (Serratia liquefaciens MT49)
MKYLASFRTTLKISRYLFRVLAIMLWSLGALLTTFYILNILHQKESDIRQDYNLNFDQAQ
GYIRHSADIIRDIKYMAENRLNGSVSSLDMFSGIFPGKSSPPEFFPLYPESNCSLNSTYR
SSLNSLSGLIQYWKENFVAAYDLNRVFFIGGDSLCMAEFGGSSGVANRSDALKTLHERIL
KYRNAKNQDKDNNLYWISPSQQRPDVGYLYVLTPIYIGSKLEALLGIEQTIRLEDFVTTG
NLPIAVTLLDENNEPILQLADGERNAQAPDSYPLEQAYFGYVDNYRDLIMKKALPPSSLS
IVYAVPVKTVVERFKMLILNAVLLNLLSAIVLFTLAWLFERKMFLPAEDNAFRLEEHEQF
NRKIVASAPVGICILRISDGTNILSNELAHNYINLLTHEDRDRITRIICEQQVNFVDVMT
SNNNNLQISFVHSRYRNEDVAICVLVDVSARVKMEESLQEMAAAAEQASQSKSMFLATVS
HELRTPLYGIIGNLDLLQTKALPQGVDRLVNAMNNSSGLLLKIISDILDFSKIESEQLKI
EPREFSCLEVITHIAGNYLPLVVKKRLGLYCFIEQNVPERISGDPVRLQQVLSNLLNNAI
KFTDTGCIILQVCTRGNYLEFSVRDTGVGIPEKEITRLFDPFFQVGSGVQRHFQGTGLGL
AICEKLINMMDGDIAVESEPGLGSLFTIRIPLFSAQFPIPQPSDTWQGKTLWLDIRNQRL
ESYLMEILGGYGATVLRHQGQDTAEGEVMLSDHPLMISTPLLAQIQFSIEHIGPSQETRP
GYWMHSTSTPRETLVLLNRLFGTQAESGNTLAQLPVPAKASLIDNGDIHLLVVDDHPINR
RLLSDQLSSLGYQVVTANDGVDALDVLSRNTVDIVLTDVNMPNMDGYHLTQRLREMQFAS
PVIGVTANALAEEKQRCIEAGMDNCLSKPVTLETLEQTLAFYSQQVRYVRAESEEA